Platelet hyperaggregability in patients with chest pain and angiographically normal coronary arteries
| Autor: | Nancy R. Selik, Marion I. Barnhart, Eberhard F. Mammen, Roger D. Blevins, Melvyn Rubenfire, Susan Housholder |
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| Rok vydání: | 1986 |
| Předmět: |
Adult
Male medicine.medical_specialty Epinephrine Platelet Aggregation Chest pain Coronary Angiography Angina Pectoris chemistry.chemical_compound Internal medicine medicine Cell Adhesion Humans Clinical significance Platelet business.industry Sticky platelet syndrome Venous Plasma Middle Aged medicine.disease Peripheral Adenosine Diphosphate Adenosine diphosphate Microscopy Electron chemistry Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | The American journal of cardiology. 57(8) |
| ISSN: | 0002-9149 |
| Popis: | Forty-one patients with chest pain and angiographically normal coronary arteries were studied for platelet abnormalities. Patients with conditions known or suspected to be associated with chest pain or platelet dysfunction were excluded. After coronary angiography and 2-week withdrawal from all medications, platelet aggregometry was performed using peripheral venous plasma samples and 3 concentrations of adenosine diphosphate, 2.34, 1.17 and 0.58 microM, and epinephrine, 11, 1.1 and 0.55 microM, as stimuli. Platelet morphology in response to surface contact (adhesion) was evaluated by transmission electron microscopy to determine the percentage of platelets in the round/abortive (inactive), dendritic (intermediate) and spread (activated) forms. Plasma specimens obtained from healthy volunteers of similar age and sex were analyzed in parallel and served as control subjects. Compared with control subjects, patients had increased aggregation at all concentrations of both adenosine diphosphate and epinephrine (p less than 0.001). Patients also had fewer platelets in the dendritic form and more in the round/abortive and spread forms. Thus, patients with chest pain and normal coronary arteries have platelet hyperaggregability in vitro, although the clinical relevance of this finding is unclear. |
| Databáze: | OpenAIRE |
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