Changes in epidemiology, clinical features and severity of influenza A (H1N1) 2009 pneumonia in the first post-pandemic influenza season
| Autor: | Anabel Fernández Navarro, Jesús Rodríguez-Baño, Carolina Garcia-Vidal, Juan Bautista Gutiérrez Aroca, Tomàs Pumarola Suñe, Jordi Niubo, Juan Gálvez-Acebal, Antoni Payeras-Cifre, Lara García-Álvarez, José A. Oteo, Diego Viasus, Jordi Carratala, Sarah CARO BRAGADO, Francisco Lopez-Medrano, Asunción Moreno Camacho, Elisa Cordero |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Adolescent Critical Care Pneumonia Viral medicine.disease_cause Antiviral Agents post-pandemic period influenza A (H1N1) 2009 Cohort Studies Young Adult Age Distribution Influenza A Virus H1N1 Subtype Pregnancy Internal medicine Intensive care Influenza Human Pandemic Epidemiology medicine Influenza A virus Humans pneumonia Prospective Studies Hospitals Teaching Intensive care medicine Prospective cohort study Pandemics Aged Aged 80 and over business.industry virus diseases Clinical features General Medicine Length of Stay Middle Aged medicine.disease Respiration Artificial mortality Pneumonia Treatment Outcome Infectious Diseases Respiratory failure Spain Female business Cohort study |
| Zdroj: | Clinical Microbiology and Infection. 18:E55-E62 |
| ISSN: | 1198-743X |
| DOI: | 10.1111/j.1469-0691.2011.03753.x |
| Popis: | Although the influenza A (H1N1) 2009 virus is expected to circulate as a seasonal virus for some years after the pandemic period, its behaviour cannot be predicted. We analysed a prospective cohort study of hospitalized adults with influenza A (H1N1) 2009 pneumonia at 14 teaching hospitals in Spain to compare the epidemiology, clinical features and outcomes of influenza A (H1N1) 2009 pneumonia between the pandemic period and the first post-pandemic influenza season. A total of 348 patients were included: 234 during the pandemic period and 114 during the first post-pandemic influenza season. Patients during the post-pandemic period were older and more likely to have chronic obstructive pulmonary disease, chronic kidney disease and cancer than the others. Septic shock, altered mental status and respiratory failure on arrival at hospital were significantly more common during the post-pandemic period. Time from illness onset to receipt of antiviral therapy was also longer during this period. Early antiviral therapy was less frequently administered to patients during the post-pandemic period (22.9% versus 10.9%; p 0.009). In addition, length of stay was longer, and need for mechanical ventilation and intensive-care unit admission were significantly higher during the post-pandemic period. In-hospital mortality (5.1% versus 21.2%; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|