Quantitative screening of stilbenes and zeranol and its related residues and natural precursors in veal liver by gas chromatography-mass spectrometry
| Autor: | Leslie C Dickson, Adrian C. E. Fesser, James D MacNeil, Del McKenzie, Roderick Costain |
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| Rok vydání: | 2009 |
| Předmět: |
Chromatography
Sheep General Chemistry Mass spectrometry Drug Residues Gas Chromatography-Mass Spectrometry chemistry.chemical_compound chemistry Liver Stilbenes Screening method Zeranol Organic chemistry Animals Zearalenone Zearalanone Gas chromatography Estrogens Non-Steroidal Gas chromatography–mass spectrometry General Agricultural and Biological Sciences Analysis method |
| Zdroj: | Journal of agricultural and food chemistry. 57(15) |
| ISSN: | 1520-5118 |
| Popis: | An existing gas chromatography-mass spectrometry-based quantitative screening method for the regulatory analysis of the resorcylic acid lactones zeranol, taleranol, and zearalanone and the stilbene anabolic steroids diethylstilbestrol and dienestrol was extended to include natural precursors of zeranol (zearalenone, alpha-zearalenol, and beta-zearalenol) in veal liver. No changes in sample preparation were required; the instrumental conditions were selected to effect a suitable chromatographic separation and detection of the analytes. Validation experiments were performed to verify the performance and applicability of the extended method for the quantitative screening of the original and additional analytes in veal liver in the concentration range from 0.5 to 2.0 microg/kg. The limits of detection were 0.08-0.19 microg/kg. The limits of quantitation were 0.27-0.64 microg/kg. Recoveries were 29-67%. Combined relative measurement uncertainty estimates were 6-21%. |
| Databáze: | OpenAIRE |
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