Treatment of acute myeloid leukemia in children: A practical perspective
| Autor: | Kuang-Yueh Chiang, Yogi Raj Chopra, Johann Hitzler, Grace Egan, Stephanie Mourad |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Standard of care medicine.medical_treatment Disease Hematopoietic stem cell transplantation Pediatric AML 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Clinical investigation Internal medicine medicine Humans Transplantation Homologous Child neoplasms Retrospective Studies business.industry Pediatric acute myeloid leukemia Hematopoietic Stem Cell Transplantation Myeloid leukemia Hematology Molecular diagnostics Prognosis Leukemia Myeloid Acute fms-Like Tyrosine Kinase 3 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Mutation business 030215 immunology |
| Zdroj: | Pediatric bloodcancerREFERENCES. 68(7) |
| ISSN: | 1545-5017 |
| Popis: | Pediatric acute myeloid leukemia (AML) is a heterogeneous disease that requires a multifaceted treatment approach. Although outcomes for low-risk AML have improved significantly over recent decades, high-risk AML continues to be associated with an adverse prognosis. Recent advances in molecular diagnostics, risk stratification, and supportive care have contributed to improvements in outcomes in pediatric AML. Targeted approaches, for example, the use of tyrosine kinase inhibitors to treat FLT3-ITD AML, offer promise and are currently undergoing clinical investigation in pediatric patients. New approaches to hematopoietic stem cell transplantation, including the use of haploidentical donors, are significantly expanding donor options for patients with high-risk AML. This review provides an overview of recent advances in the treatment of pediatric AML that are likely to have clinical impact and reshape the standard of care. |
| Databáze: | OpenAIRE |
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