Biologic therapy in the management of asthma
| Autor: | William J. Calhoun, Jennifer L. McCracken, Julia W. Tripple |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Immunology Omalizumab Immunoglobulin E Anti-asthmatic Agent Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Immunology and Allergy Animals Humans 030212 general & internal medicine Anti-Asthmatic Agents Molecular Targeted Therapy Intensive care medicine Asthma Randomized Controlled Trials as Topic Inflammation Leukotriene biology business.industry Benralizumab medicine.disease United States respiratory tract diseases Biological Therapy Eosinophils 030228 respiratory system chemistry biology.protein Interleukin 17 Interleukin-5 business Mepolizumab medicine.drug |
| Zdroj: | Current opinion in allergy and clinical immunology. 16(4) |
| ISSN: | 1473-6322 |
| Popis: | Current asthma management relies on inhaled corticosteroids, but some asthma is not well controlled with inhaled steroids alone or in combination with long-acting bronchodilators or leukotriene pathway inhibitors. The field of biologic therapy has grown dramatically in the past two decades, with current availability of three molecules, with two distinct and highly selective approaches to interfering with the allergic and eosinophilic airway inflammation common to most asthma. This review summarizes current and future options for incorporating biologic therapy into the overall management of asthma.Two new biologic agents have been recently introduced in the United States market, supported by well controlled, randomized clinical trials. These trials have provided insight into the types of patients who are most likely to benefit from these novel agents.In asthma patients with frequent exacerbations, the addition of a biologic agent targeting the interleukin-5 pathway, or immunoglobulin E, can significantly reduce exacerbations and improve asthma control. The clinical predictors of utility of specific agents overlap with one another, highlighting the importance of clinical judgment in the overall management of this complex disorder. |
| Databáze: | OpenAIRE |
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