Retinal findings in hospitalised patients with severe COVID-19
| Autor: | Hebert Toshiaki Sakuma, Priscila Alves Nascimento, Fernando Luiz Afonso Fonseca, Glaucia Luciano da Veiga, Luciano Rabello Netto Cirillo, Leonardo Amarante Pereira, Vagner Loduca Lima, Larissa Caroline Mansano Soares, Julio Zaki Abucham-Neto |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Eye Infections Viral Severity of Illness Index Pallor Retina chemistry.chemical_compound Cellular and Molecular Neuroscience Internal medicine medicine Humans Aged Aged 80 and over medicine.diagnostic_test business.industry SARS-CoV-2 Medical record Confounding COVID-19 Retinal Hemorrhage Retinal Middle Aged Pathophysiology Sensory Systems Cotton wool spots Ophthalmology medicine.anatomical_structure Cross-Sectional Studies chemistry Eye examination Female medicine.symptom business Brazil |
| Zdroj: | British Journal of Ophthalmology |
| ISSN: | 1468-2079 0007-1161 |
| DOI: | 10.1136/bjophthalmol-2020-317576 |
| Popis: | AimTo identify retinal findings using dilated eye examination, which are possibly related to SARS-CoV-2 infection in hospitalised patients with confirmed severe COVID-19.MethodsIn this cross-sectional study, hospitalised patients with confirmed severe COVID-19 in a single referral centre for the treatment of COVID-19, in Santo André, São Paulo Metropolitan Area, Brazil, underwent dilated eye examination of both eyes performed by a retina specialist. Findings were recorded using a portable digital fundus camera. Retinographies were analysed by two retina specialists. Medical records were reviewed for assessment of patient demographics, baseline comorbidities and clinical data.ResultsThere were a total of 18 patients, nine (50%) male, median IQR age of 62.5 (12) years. Ten of the 18 patients (55.6%; 95% CI 33.7 to 75.4) had abnormalities on dilated eye examination. The main findings were flame-shaped haemorrhages (N=4; 22.2%; 95% CI 9.0 to 45.2) and ischaemic pattern lesions (cotton wool spots and retinal sectorial pallor) (N=4; 22.2%; 95% CI 9.0 to 45.2), with one patient having both cotton wool spots and flame-shaped haemorrhages.ConclusionThese findings suggest that patients with severe COVID-19 have acute vascular lesions of the inner retina including flame-shaped haemorrhages and cotton wool spots. Further studies controlling for confounding factors are necessary to properly assess these findings so as to increase the understanding of COVID-19 pathophysiology and to identify new therapies. |
| Databáze: | OpenAIRE |
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