Change in diastolic left ventricular filling after one year of antihypertensive treatment: The Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study
| Autor: | Jens Rokkedal, Eva Gerdts, Richard B. Devereux, Vasilios Papademetriou, Vittorio Palmieri, Kristian Wachtell, Björn Dahlöf, Jonathan N. Bella, Tapio Aalto |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Heart disease Heart Ventricles Diastole Blood Pressure Losartan Ventricular Function Left Muscle hypertrophy Electrocardiography Physiology (medical) Internal medicine medicine Humans Heart Atria Antihypertensive Agents Aged medicine.diagnostic_test business.industry Remission Induction Atenolol medicine.disease Blood pressure Treatment Outcome Echocardiography Hypertension Multivariate Analysis Cardiology Female Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine Isovolumic relaxation time business medicine.drug Follow-Up Studies |
| Zdroj: | Circulation. 105(9) |
| ISSN: | 1524-4539 |
| Popis: | Background — It is well established that hypertensive patients with left ventricular (LV) hypertrophy have impaired diastolic filling. However, the impact of antihypertensive treatment and LV mass reduction on LV diastolic filling remains unclear. Methods and Results — Echocardiograms were recorded in 728 hypertensive patients with ECG-verified LV hypertrophy (Cornell voltage-duration or Sokolow-Lyon) at baseline and after 1 year of blinded treatment with either losartan or atenolol-based regimen. Systolic and diastolic blood pressures (BP) were reduced on average 23/11 mm Hg; isovolumic relaxation time and E/A ratio became more normal, and LV inflow deceleration time prolonged (all P P P P =NS). IVRT shortening was independently associated with reduction in LV mass. Increase in E/A ratio was independently associated with reduction in diastolic BP, and increase in the deceleration time was independently associated with reduced end-systolic relative wall thickness. Conclusions — Antihypertensive therapy resulting in LV mass or relative wall thickness regression is associated with significant improvement of diastolic filling parameters related to active relaxation and passive chamber stiffness compared with patients without regression, independent of BP reduction; however, abnormalities of diastolic LV filling remain common. |
| Databáze: | OpenAIRE |
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