Circulating Oxidized LDL Is a Useful Marker for Identifying Patients With Coronary Artery Disease
| Autor: | Raymond Verhaeghe, Frans Van de Werf, Paul Holvoet, Peter Verhamme, Erik Muls, Ann Mertens, Désiré Collen, Kris Bogaerts, G. Beyens |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Oxidized low density lipoprotein Coronary Disease Coronary Artery Disease Sensitivity and Specificity Gastroenterology Coronary artery disease chemistry.chemical_compound High-density lipoprotein Risk Factors Diabetes mellitus Internal medicine medicine Humans Aged Cholesterol business.industry Middle Aged medicine.disease Coronary Arteriosclerosis Lipoproteins LDL Endocrinology Blood pressure chemistry Biological Markers Female Cardiology and Cardiovascular Medicine business Oxidation-Reduction Biomarkers Global risk Oxidized ldl |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 21:844-848 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/01.atv.21.5.844 |
| Popis: | Abstract —Our aim was to determine the usefulness of circulating oxidized low density lipoprotein (LDL) in the identification of patients with coronary artery disease (CAD). A total of 304 subjects were studied: 178 patients with angiographically proven CAD and 126 age-matched subjects without clinical evidence of cardiovascular disease. The Global Risk Assessment Score (GRAS) was calculated on the basis of age, total and high density lipoprotein cholesterol, blood pressure, diabetes mellitus, and smoking. Levels of circulating oxidized LDL were measured in a monoclonal antibody 4E6–based competition ELISA. Compared with control subjects, CAD patients had higher levels of circulating oxidized LDL ( P P P |
| Databáze: | OpenAIRE |
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