Effects of endurance training on hippocampus DJ-1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats

Autor: Seyed A Tavakoli, Mohammad Kurd, Vahid Valipour Dehnou, Daniel Gahreman
Rok vydání: 2018
Předmět:
0301 basic medicine
Blood Glucose
Male
medicine.medical_specialty
Basic Science and Research
Endocrinology
Diabetes and Metabolism
Protein Deglycase DJ-1
Hippocampus
Diseases of the endocrine glands. Clinical endocrinology
Receptor
Cannabinoid
CB2
03 medical and health sciences
0302 clinical medicine
Endurance training
Internal medicine
Diabetes mellitus
Physical Conditioning
Animal
Internal Medicine
medicine
Cannabinoid receptor type 2
Diabetes Mellitus
Aerobic exercise
Hippocampus (mythology)
Animals
Rats
Wistar
Inverse correlation
business.industry
Physical activity
Neurodegenerative diseases
General Medicine
Articles
RC648-665
medicine.disease
Metabolic syndrome
Disease Models
Animal
Endurance Training
030104 developmental biology
Endocrinology
Significant positive correlation
lipids (amino acids
peptides
and proteins)
Original Article
business
030217 neurology & neurosurgery
Zdroj: Journal of Diabetes Investigation
Journal of Diabetes Investigation, Vol 10, Iss 1, Pp 43-50 (2019)
ISSN: 2040-1124
Popis: Aims/Introduction To investigate the effect of endurance training on hippocampus DJ‐1 and cannabinoid receptor type 2 (CB 2) protein and blood glucose concentration in diabetic rats. Materials and Methods A total of 32 rats were randomly divided into diabetic (D), diabetic and exercise (DE), exercise (E) and control (C) groups. The endurance training was carried out five times per week for 6 weeks. The hippocampus DJ‐1 and CB 2 were measured using an enzyme‐linked immunosorbent assay method. Results The level of DJ‐1 in the D group was significantly higher than the other groups (P ≤ 0.01). However, the level of DJ‐1 was not significantly different between the C, E and DE groups. In addition, the level of CB 2 was significantly lower in the D group compared with the other groups (P ≤ 0.01). Blood glucose was significantly higher in the D group compared with the DE group (P ≤ 0.05). Furthermore, a significant positive correlation between the level of DJ‐1 and blood glucose was observed (r = 0.67, P ≤ 0.001). There was also a significant inverse correlation between the level of CB 2 and blood glucose (r = −0.77, P ≤ 0.001). Conclusions The results of this study suggest that the level of DJ‐1 and CB 2 might change in response to diabetes, and regular aerobic exercise could mediate the effect of DJ‐1 and CB 2 on diabetes‐induced neurodegenerative diseases.
Databáze: OpenAIRE
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