Modeling the finger instability in an expanding cell monolayer
| Autor: | Vincent Hakim, Andrea Ravasio, Nir S. Gov, Victoria Tarle |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Cell
Cell Culture Techniques Biophysics Embryonic Development Models Biological Biochemistry Instability Cell Movement Monolayer medicine Animals Humans Computer Simulation Neoplasm Invasiveness Cell Proliferation Positive feedback Physics Wound Healing Collective cell migration Collective motion Actomyosin Anatomy Elasticity Biomechanical Phenomena medicine.anatomical_structure Cell Surface Extensions Restoring force |
| Zdroj: | Integrative Biology. 7:1218-1227 |
| ISSN: | 1757-9708 1757-9694 |
| DOI: | 10.1039/c5ib00092k |
| Popis: | Collective motion occurs in many biological processes, such as wound healing, tumor invasion and embryogenesis. Experiments of cell monolayer migration have revealed the spontaneous formation of finger-like instabilities, with leader cells at their tips. We present a particle-based model for collective cell migration, based on several elements that have been found experimentally to influence cellular movement. Inside the bulk we include velocity alignment interactions between neighboring cells. At the border contour of the layer we introduce the following additional forces: surface-elasticity restoring force, curvature-dependent positive feedback, and contractile acto-myosin cables. We find that the curvature-driven instability at the layer edge is necessary and sufficient for the formation of cellular fingers, which are in good agreement with experimental observations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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