Use of bed rest and head-down tilt to simulate spaceflight-induce immune system changes
| Autor: | Didier A. Schmitt, Laurance Schaffar, Michel Abbal, Victor S. Schneider, Gerald Sonnenfeld, Robert N. Ferebee, J. Reuben, Dorothy E. Lewis, Anne Koebel, Karin C. Loftin, Gerald R. Taylor |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Receptor expression T-Lymphocytes Immunology Immunoglobulins Biology Spaceflight Bed rest Lymphocyte Activation Peripheral blood mononuclear cell law.invention Head-Down Tilt Leukocyte Count Immune system Hypokinesia law Reference Values Virology Internal medicine medicine Humans Weightlessness Cell Biology Space Flight Endocrinology Immune System Antibody Formation Interleukin-2 medicine.symptom Bed Rest |
| Zdroj: | Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 16(2) |
| ISSN: | 1079-9907 |
| Popis: | Bed rest, both with and without head-down tilt, has been extensively used as an earth-bound analog to study physiologic effects mimicking those occurring in weightlessness during spaceflight. We have been able to show in six subjects that 4 weeks of head-down tilt bed rest induces a significant decrease in interleukin-2 secretion by PHA-stimulated T lymphocytes. Another study, lasting 113 days, with two subjects showed a decreased interleukin-2 receptor expression in PHA-stimulated peripheral blood mononuclear cells but a decreased interleukin-2 production in one subject only. Under the same conditions, interleukin-1 production was largely increased in both subjects. Several other immune parameters were also analyzed. Increased interleukin-1 production could contribute to bone mineral loss encountered during bed rest and decreased interleukin-2 secretion could play a role in the appearance of infectious diseases often observed during bed red. |
| Databáze: | OpenAIRE |
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