Pancreatic neuroendocrine microadenomatosis presenting as a functional VIPoma
| Autor: | Jamie K Murphy, Daniel F Klink, Alexei A Krainev, Gabie K B Ong, Jonathan M. Saxe, Viney K. Mathavan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Vasoactive intestinal peptide Metabolic acidosis Case Report medicine.disease Pancreaticoduodenectomy Gastroenterology Hypokalemia Work-up 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Internal medicine medicine 030211 gastroenterology & hepatology Surgery medicine.symptom business Pancreas Multiple endocrine neoplasia VIPoma |
| Zdroj: | Journal of Surgical Case Reports |
| ISSN: | 2042-8812 |
| Popis: | Pancreatic microadenomas are benign tumors of neuroendocrine origin less than 5 mm in size. Whereas most microadenomas are non-functional; a few rare functional pancreatic microadenomas have been described in the setting of multiple endocrine neoplasia type one (MEN-1). In this report, we describe a unique case of multiple functional microadenomas of the pancreatic head in a patient who presented with persistent secretory diarrhea, refractory hypokalemia, metabolic acidosis and elevated plasma vasoactive intestinal peptide (VIP) levels. Following extensive serologic, radiographic and endoscopic work up, our patient underwent open pancreaticoduodenectomy with subsequent resolution of diarrheal symptoms and electrolyte abnormalities on postoperative follow up. |
| Databáze: | OpenAIRE |
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