A novel prognostic model to predict outcome of artificial liver support system treatment

Autor:	Jin Shang, Hong Tang, Mengqiao Wang, Yan Xu, Yuan-Ji Ma, Fang Chen, Lang Bai, Chang-Hai Liu, Qin Wen
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Oncology Adult Male medicine.medical_specialty medicine.medical_treatment Science Decision tree 030230 surgery Liver transplantation Logistic regression Outcome (game theory) Article 03 medical and health sciences 0302 clinical medicine Artificial liver Internal medicine Medicine Humans Multidisciplinary Hepatology business.industry Decision Trees Acute-On-Chronic Liver Failure Hepatitis B Models Theoretical medicine.disease Prognosis Liver Artificial Logistic Models ROC Curve Outcomes research Area Under Curve Multivariate Analysis Prognostic model Infectious diseases 030211 gastroenterology & hepatology Support system Female business
Zdroj:	Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) Scientific Reports
ISSN:	2045-2322
Popis:	The prognosis of Artificial liver support system (ALSS) for hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is hard to be expected, which results in multiple operations of ALSS and excessive consumption of plasma, increase in clinical cost. A total of 375 HBV-ACLF patients receiving ALSS treatment were randomly divided a train set and an independent test set. Logistic regression analysis was conducted and a decision tree was built based on 3-month survival as outcome. The ratio of total bilirubin before and after the first time of ALSS treatment was the most significant prognostic factor, we named it RPTB. Further, a decision tree based on the multivariate logistic regression model using CTP score and the RPTB was built, dividing patients into 3 main groups such as favorable prognosis group, moderate prognosis group and poor prognosis group. A clearly-presented and easily-understood decision tree was built with a good predictive value of prognosis in HBV-related ACLF patients after first-time ALSS treatment. It will help maximal the therapeutic value of ALSS treatment and may play an important role in organ allocation for liver transplantation in the future.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39042a2b5dfe0939ae44b93c70271008 https://doaj.org/article/1e83c8c5f3be4e799470db2322c9a869 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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