Diagnosis and Management of Ménétrier Disease in Children: A Case Series Review
| Autor: | Yvan Vandenplas, Jasmina Krikilion, Elvira Ingrid Levy |
|---|---|
| Přispěvatelé: | Pediatrics, Faculty of Medicine and Pharmacy, Clinical sciences, Growth and Development |
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Abdominal pain Anorexia Disease Hypertrophy mucosal folds 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Biopsy medicine Pediatrics Perinatology and Child Health Ménétrier disease Hypoalbuminemia Letter to the Editor Hepatology medicine.diagnostic_test business.industry Gold standard Gastroenterology Transforming growth factor alpha medicine.disease Hypo-proteinemia Pediatrics Perinatology and Child Health Vomiting Etiology 030211 gastroenterology & hepatology medicine.symptom business |
| Zdroj: | Pediatric Gastroenterology, Hepatology & Nutrition |
| ISSN: | 2234-8840 2234-8646 |
| Popis: | Purpose Menetrier disease (MD) was first described in 1888, and 50 cases have been reported until now. We aimed to discuss the etiology, diagnostics, and management of MD in children. Methods We searched for case reports published from 2014 till 2019 in English using PubMed. Articles were selected using subject headings and key words of interest to the topic. Interesting references of the included articles were also included. Results The pathophysiology of MD is still uncertain. However, overexpression of transforming growth factor alpha with transformation of the gastric mucosa has been observed, which may be mediated by genetics and provoked by an infectious trigger. Clinically, MD is diagnosed by abdominal pain, vomiting, anorexia, and edema secondary to hypoalbuminemia. A gastroscopy with biopsy is the gold standard for the diagnosis of MD. In children, the disease is self-limiting and only requires supportive treatment. In general, children have a good prognosis and recover spontaneously within a few weeks. Conclusion Few pediatric cases of MD have been described in recent years, and with all different etiology. Endoscopy with biopsy remains the golden standard for the diagnosis of MD, and in children, the disease is self-limiting. |
| Databáze: | OpenAIRE |
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