Modified Spinning Top Homogeneous Spray Apparatus for Use in Experimental Respiratory Disease Studies
| Autor: | Edgar W. Larson, Joseph W. Dominik, Harold W. Young |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1974 |
| Předmět: |
Materials science
complex mixtures General Biochemistry Genetics and Molecular Biology law.invention Mice Optical microscope law Nasopharynx Animals General Pharmacology Toxicology and Pharmaceutics Composite material Particle Size Spinning Lung Respiratory Tract Infections Environmental Microbiology and Ecology Aerosols General Immunology and Microbiology General Medicine Anatomy Orthomyxoviridae Aerosol Trachea Biological safety Disease Models Animal Homogeneous Particle-size distribution Particle size |
| Popis: | The May spinning top generator was adapted to a modified Henderson tube for producing large aerosol particles (>4 μm) to obtain almost exclusive upper respiratory tract deposition of infectious aerosols in exposed mice. The system was installed in a biological safety cabinet to permit experimentation with pathogens. A novel mechanism utilizing parts from a machinists micrometer and the mechanical stage from a light microscope was developed for the spinning top generator as a means for precisely positioning the liquid feed needle. Aerosol light-scatter properties were continuously analyzed to provide relative measures of particle size distribution and aerosol concentration. When mice were exposed to influenza virus aerosols in which none of the virus was contained in particles with aerodynamic diameters |
| Databáze: | OpenAIRE |
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