Systemic markers of collagen metabolism and vitamin C in smokers and non-smokers with pelvic organ prolapse
| Autor: | Steven D. Kleeman, Rachel N. Pauls, Susan H. Oakley, M. Victoria Estanol, Angela N. Fellner, Catrina C. Crisp |
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| Rok vydání: | 2015 |
| Předmět: |
Vitamin
medicine.medical_specialty genetic structures Physiology Ascorbic Acid behavioral disciplines and activities Pelvic Organ Prolapse chemistry.chemical_compound medicine Humans Aged Gynecology Pelvic organ Vitamin C urogenital system business.industry Smoking Obstetrics and Gynecology Matrix metalloproteinase 9 Middle Aged Peptide Fragments Pathophysiology body regions Procollagen peptidase Cross-Sectional Studies Matrix Metalloproteinase 9 Reproductive Medicine chemistry Collagen metabolism Female Smoking status Collagen business Procollagen psychological phenomena and processes |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 184:58-64 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/j.ejogrb.2014.11.009 |
| Popis: | Objective To evaluate systemic markers of collagen metabolism and vitamin C in female smokers with pelvic organ prolapse (POP). Secondary aims were to compare these levels in women based on prolapse or smoking history alone. Study design This was a cross-sectional study with four groups: smokers with POP, non-smokers with POP, smokers without POP and non-smokers without POP. Subjects were age-matched based on smoking history and presence of POP. All underwent a fasting blood panel, including plasma procollagen 1-N propeptide (P1NP), matrix metalloproteinase 9 (MMP-9), and vitamin C. Results Ninety-six subjects were enrolled. There were no differences for any demographics other than stage of prolapse, which was highest in non-smokers with POP. Significant variations in the levels of vitamin C and MMP-9 were noted among the four groups. Smokers with POP had lower levels of vitamin C and higher levels of MMP-9, compared to non-smokers with POP, but this relationship was not statistically significant. However, when contrasting smokers without POP to non-smokers without POP, significant differences in both vitamin C and MMP-9 were documented, confirming an impact of smoking on these markers. Notwithstanding, when evaluated independent of smoking status, vitamin C and MMP-9 levels in women with POP were similar to those of women without POP. Conclusion Lower vitamin C and higher MMP-9 among smokers confirms the usefulness of such markers in documenting the smoking's impact on collagen. However, the lack of a difference based on POP suggests these are poor measures for understanding the pathophysiology of this disorder. |
| Databáze: | OpenAIRE |
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