Risk of chronic Q fever in patients with cardiac valvulopathy, seven years after a large epidemic in the Netherlands

Autor: Arko Scheepmaker, Peter M. Schneeberger, Wim van der Hoek, Marit M A de Lange, Monique Leclercq
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Bacterial Diseases
Male
Cross-sectional study
Epidemiology
Physiology
Heart Valve Diseases
Pathology and Laboratory Medicine
Biochemistry
Serology
0302 clinical medicine
Immune Physiology
Chronic Q fever
Medicine and Health Sciences
030212 general & internal medicine
Netherlands
Stenosis
Aged
80 and over
Multidisciplinary
Immune System Proteins
biology
Endocarditis
Middle Aged
Antibodies
Bacterial
Bacterial Pathogens
Infectious Diseases
Medical Microbiology
Coxiella burnetii
Medicine
Female
Pathogens
Q Fever
Research Article
Adult
medicine.medical_specialty
Science
030106 microbiology
Immunology
Cardiology
Prosthetic Device Infections
Q fever
Microbiology
Antibodies
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Internal medicine
medicine
Humans
Epidemics
Microbial Pathogens
Aged
business.industry
Biology and Life Sciences
Proteins
medicine.disease
biology.organism_classification
Chronic infection
Cross-Sectional Studies
Medical Risk Factors
Immunoglobulin G
Chronic Disease
business
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 8, p e0221247 (2019)
ISSN: 1932-6203
Popis: BackgroundFrom 2007 through 2010, a large epidemic of acute Q fever occurred in the Netherlands. Patients with cardiac valvulopathy are at high risk to develop chronic Q fever after an acute infection. This patient group was not routinely screened, so it is unknown whether all their chronic infections were diagnosed. This study aims to investigate how many chronic Q fever patients can be identified by routinely screening patients with valvulopathy and to establish whether the policy of not screening should be changed.MethodsIn a cross-sectional study (2016-2017) in a hospital at the epicentre of the Q fever epidemic, a blood sample was taken from patients 18 years and older who presented with cardiac valvulopathy. The sample was tested for IgG antibodies against phase I and II of Coxiella burnetii using an immunofluorescence assay. An IgG phase II titre of ≥1:64 was considered serological evidence of a previous Q fever infection. An IgG phase I titre of ≥1:512 was considered suspicious for a chronic infection, and these patients were referred for medical examination.ResultsOf the 904 included patients, 133 (15%) had evidence of a previous C. burnetii infection, of whom 6 (5%) had a chronic infection on medical examination.ConclusionsIn a group of high-risk patients with a heart valve defect, we diagnosed new chronic Q fever infections seven years after the epidemic, emphasizing the need for screening of this group to prevent complications in those not yet diagnosed in epidemic areas.
Databáze: OpenAIRE
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