Mean Corpuscular Volume as a Prognostic Factor for Patients With Habitual Alcohol or Tobacco Use After Esophagectomy
| Autor: | Shao-bin Chen, Peng-fei Zhan, Shu-jie Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
squamous cell carcinoma
Cancer Research medicine.medical_specialty Prognostic factor Tobacco use Multivariate analysis medicine.medical_treatment Alcohol Elevated MCV Gastroenterology esophageal neoplasm surgery chemistry.chemical_compound Internal medicine Medicine Mean corpuscular volume RC254-282 Original Research medicine.diagnostic_test mean corpuscular volume business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens chemistry Oncology Esophagectomy prognosis business Body mass index circulatory and respiratory physiology |
| Zdroj: | Frontiers in Oncology, Vol 11 (2021) Frontiers in Oncology |
| DOI: | 10.3389/fonc.2021.752229/full |
| Popis: | BackgroundThe goal of this study was to investigate the impact of mean corpuscular volume (MCV) in patients with esophageal squamous cell carcinoma (ESCC) who underwent surgical resection.MethodsA total of 615 patients with ESCC who underwent esophagectomy were analyzed. Patients were divided into two groups according to the standard MCV: the high MCV group (>100 fl) and the low MCV group (≤100 fl). Survival analyses were performed to calculate overall survival (OS) and cancer-specific survival (CSS) and investigate the independent prognostic factors.ResultsFifty-one patients (8.3%) were in the high MCV group, and the other 564 patients (91.7%) were defined as the low MCV group. MCV was significantly correlated with sex, habitual alcohol or tobacco use, tumor length, body mass index, and multiple primary malignancies (P < 0.05). Elevated MCV was significantly correlated with poor survival in univariate and multivariate analyses. However, in subgroup analyses, MCV was found to be correlated with survival only in patients with alcohol or tobacco consumption and not in patients without alcohol or tobacco consumption.ConclusionsPretreatment MCV was correlated with survival in ESCC patients after esophagectomy. However, its prognostic value might only exist in patients with alcohol or tobacco consumption. |
| Databáze: | OpenAIRE |
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