Risk Factors Associated With Pediatric Acute Recurrent and Chronic Pancreatitis Lessons From INSPPIRE
| Autor: | Joseph J. Palermo, Cheryl E. Gariepy, Sohail Z. Husain, Mark E. Lowe, Veronique D. Morinville, Tanja Gonska, Melvin B. Heyman, Aliye Uc, John F. Pohl, Chee Y. Ooi, Tom K. Lin, Bradley A. Barth, Michael Wilschanski, Steven D. Freedman, M. Bridget Zimmerman, Melena D. Bellin, Sarah Jane Schwarzenberg, Ryan Himes, Maisam Abu-El-Haija, Matthew J. Giefer, Douglas S. Fishman, Peter R. Durie, David M. Troendle, Soma Kumar, Steven L. Werlin |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
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| Zdroj: | Kumar, S; Ooi, CY; Werlin, S; Abu-El-Haija, M; Barth, B; Bellin, MD; et al.(2016). Risk Factors Associated With Pediatric Acute Recurrent and Chronic Pancreatitis Lessons From INSPPIRE. JAMA PEDIATRICS, 170(6), 562-569. doi: 10.1001/jamapediatrics.2015.4955. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/558019pv JAMA pediatrics, vol 170, iss 6 |
| DOI: | 10.1001/jamapediatrics.2015.4955. |
| Popis: | ImportancePediatric acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) are poorly understood.ObjectiveTo characterize and identify risk factors associated with ARP and CP in childhood.Design, setting, and participantsA multinational cross-sectional study of children with ARP or CP at the time of enrollment to the INSPPIRE (International Study Group of Pediatric Pancreatitis: In Search for a Cure) study at participant institutions of the INSPPIRE Consortium. From August 22, 2012, to February 8, 2015, 155 children with ARP and 146 with CP (aged ≤19 years) were enrolled. Their demographic and clinical information was entered into the REDCap (Research Electronic Data Capture) database at the 15 centers. Differences were analyzed using 2-sample t test or Wilcoxon rank sum test for continuous variables and Pearson χ2 test or Fisher exact test for categorical variables. Disease burden variables (pain variables, hospital/emergency department visits, missed school days) were compared using Wilcoxon rank sum test.Main outcomes and measuresDemographic characteristics, risk factors, abdominal pain, and disease burden.ResultsA total of 301 children were enrolled (mean [SD] age, 11.9 [4.5] years; 172 [57%] female); 155 had ARP and 146 had CP. The majority of children with CP (123 of 146 [84%]) reported prior recurrent episodes of acute pancreatitis. Sex distribution was similar between the groups (57% female in both). Hispanic children were less likely to have CP than ARP (17% vs 28%, respectively; odds ratio [OR] = 0.51; 95% CI, 0.29-0.92; P = .02). At least 1 gene mutation in pancreatitis-related genes was found in 48% of patients with ARP vs 73% of patients with CP (P |
| Databáze: | OpenAIRE |
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