Cognitive-Enhancing Effect of a Hydroethanolic Extract of Crinum macowanii against Memory Impairment Induced by Aluminum Chloride in BALB/c Mice

Autor:	Louis L. Gadaga, Mohammed S. Jilani, Dexter Tagwireyi, Cosmas Mutsimhu, Charles C. Maponga
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	0301 basic medicine Male Zimbabwe Article Subject Positive control Morris water navigation task Neurosciences. Biological psychiatry. Neuropsychiatry Crinum macowanii Plant Roots BALB/c 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Crinum medicine Memory impairment Aluminum Chloride Animals Donepezil Maze Learning Nootropic Agents Memory Disorders Mice Inbred BALB C biology Traditional medicine Behavior Animal Plant Extracts Recognition Psychology General Medicine biology.organism_classification Acetylcholinesterase 030104 developmental biology Neuropsychology and Physiological Psychology Neurology chemistry Neurology (clinical) 030217 neurology & neurosurgery medicine.drug RC321-571 Research Article
Zdroj:	Behavioural Neurology Behavioural Neurology, Vol 2018 (2018)
ISSN:	0953-4180
DOI:	10.1155/2018/2057219
Popis:	Crinum macowanii is a bulbous plant indigenous to many parts of Southern Africa. Extracts of C. macowanii have gained interest since the discovery of various alkaloids, few of which possess acetylcholinesterase inhibitory activity. The present study was performed to evaluate the effect of a crude hydroethanolic extract of C. macowanii against aluminum chloride-induced memory impairment in mice using the Morris water maze and the novel object recognition task. C. macowanii (10, 20, and 40 mg/kg p.o) was administered daily for five weeks, while donepezil (3 mg/kg p.o) was used as the positive control. C. macowanii at a dosage of 40 mg/kg showed a significantly lower escape latency than the negative control (P<0.0001) and was found to be comparable to donepezil 3 mg/kg in the Morris water maze test. C. macowanii at 40 mg/kg exhibited a significantly higher discrimination index than aluminum chloride-treated mice in the novel object recognition task. The results may support the usefulness of C. macowanii in the management of dementia and related illnesses.
Databáze:	OpenAIRE
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