Clinic-Cytologic Study of Conjunctivochalasis and Its Relation to Thyroid Autoimmune Diseases
| Autor: | Luis Antonio Vieira, Jeison de Nadai Barros, Luciene Barbosa de Sousa, Maria I Chiamollera, Sandra Flavia Fiorentini de Almeida |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Conjunctiva Keratoconjunctivitis Sicca Severity of Illness Index Thyroiditis Diagnosis Differential Cytology Internal medicine Severity of illness Prevalence medicine Humans Prospective Studies Prospective cohort study Aged business.industry Thyroid Thyroiditis Autoimmune Middle Aged Conjunctivochalasis medicine.disease Ophthalmology medicine.anatomical_structure Relative risk business Follow-Up Studies |
| Zdroj: | Cornea. 25:789-793 |
| ISSN: | 0277-3740 |
| DOI: | 10.1097/01.ico.0000226365.64796.fb |
| Popis: | Purpose To determine the prevalence of conjunctivochalasis in patients with immune thyroid diseases, to determine whether there is any association between the 2 diseases, and to determine cytologic study of conjunctivochalasis through the cytology impression test. Methods A clinical prospective cohort study carried out by the External Diseases Department in the Ophthalmology Sector and the Thyroid Department in the Endocrinology Sector at Federal University of Sao Paulo (UNIFESP). The patients included were divided into 2 groups following these inclusion criteria: a control group of 25 patients without thyroid diseases, confirmed after clinical and laboratory examinations (thyroid hormones), or any other ocular diseases. The study group consisted of 31 patients with thyroid diseases, the diagnosis of which was confirmed by the Endocrinology Sector. The thyroidopathies included were autoimmune diseases but excluded nonautoimmune diseases. A protocol endorsed by the UNIFESP was followed, using clinical and ophthalmological history, biomicroscopy, and impression cytology. Results Fifty-two percent of patients without thyroid diseases and 88% of patients with thyroid diseases presented with conjunctivochalasis. The risk ratio was 1.705 (Pr > chi(2) = 0.0038), indicating that there is an association between them. For the impression cytology in inferior bulbar conjunctiva, there was an association between the result of the impression cytology and conjunctivochalasis (Pearson chi(2) = 10.1190 Pr = 0.006). Conclusion The prevalence of conjunctivochalasis in patients with autoimmune thyroid diseases was 88%. Patients with autoimmune thyroidopathy presented higher percentages of conjunctivochalasis than the control group, confirming the association between them. The cytologic study showed the highest prevalence of abnormal surface features in eyes with conjunctivochalasis. |
| Databáze: | OpenAIRE |
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