Exhaled Breath Condensate: Technical and Diagnostic Aspects
| Autor: | Andreas Lappas, Panagiotis Behrakis, Efstathia Konstantinidi, Anna Tzortzi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Pathology medicine.medical_treatment Respiratory Tract Diseases MEDLINE lcsh:Medicine Review Article lcsh:Technology General Biochemistry Genetics and Molecular Biology Idiopathic pulmonary fibrosis medicine Humans Exhaled breath condensate Intensive care medicine lcsh:Science General Environmental Science Asthma Mechanical ventilation COPD business.industry lcsh:T lcsh:R General Medicine medicine.disease respiratory tract diseases Obstructive sleep apnea Breath Tests Exhalation GERD lcsh:Q business Biomarkers |
| Zdroj: | The Scientific World Journal, Vol 2015 (2015) The Scientific World Journal |
| ISSN: | 2356-6140 |
| Popis: | Purpose. The aim of this study was to evaluate the 30-year progress of research on exhaled breath condensate in a disease-based approach.Methods. We searched PubMed/Medline, ScienceDirect, and Google Scholar using the following keywords: exhaled breath condensate (EBC), biomarkers, pH, asthma, gastroesophageal reflux (GERD), smoking, COPD, lung cancer, NSCLC, mechanical ventilation, cystic fibrosis, pulmonary arterial hypertension (PAH), idiopathic pulmonary fibrosis, interstitial lung diseases, obstructive sleep apnea (OSA), and drugs.Results. We found 12600 related articles in total in Google Scholar, 1807 in ScienceDirect, and 1081 in PubMed/Medline, published from 1980 to October 2014. 228 original investigation and review articles were eligible.Conclusions. There is rapidly increasing number of innovative articles, covering all the areas of modern respiratory medicine and expanding EBC potential clinical applications to other fields of internal medicine. However, the majority of published papers represent the results of small-scale studies and thus current knowledge must be further evaluated in large cohorts. In regard to the potential clinical use of EBC-analysis, several limitations must be pointed out, including poor reproducibility of biomarkers and absence of large surveys towards determination of reference-normal values. In conclusion, contemporary EBC-analysis is an intriguing achievement, but still in early stage when it comes to its application in clinical practice. |
| Databáze: | OpenAIRE |
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