Predictors of longterm mortality in patients with and without systemic lupus erythematosus on maintenance dialysis: a comparative study
| Autor: | Ming-Jen Sheu, Chun-Hsiung Chen, Chin-Chen Chu, Hung-An Chen, Jhi-Joung Wang, Pei-Chih Chen, Chih-Chiang Chien, Yeong-Jang Lin, Chung-Tei Chou |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis medicine.medical_treatment Immunology Taiwan Kaplan-Meier Estimate Rheumatology Renal Dialysis Risk Factors Internal medicine medicine Immunology and Allergy Humans Lupus Erythematosus Systemic Longitudinal Studies Intensive care medicine Survival rate Dialysis Aged Retrospective Studies Lupus erythematosus Proportional hazards model business.industry Retrospective cohort study Middle Aged medicine.disease Prognosis Discontinuation Survival Rate Cohort Kidney Failure Chronic Regression Analysis Female business Follow-Up Studies |
| Zdroj: | The Journal of rheumatology. 38(11) |
| ISSN: | 0315-162X |
| Popis: | Objective.To compare the prognosis of patients with and without systemic lupus erythematosus (SLE) on dialysis and to determine the factors that affect survival after dialysis.Methods.We used the Taiwan National Health Insurance Research Database (NHRI-NHIRD-99182) and collected data on patients who started maintenance dialysis between 2001 and 2003. Patients were followed from the initiation of dialysis until death, discontinuation of dialysis, or the end of 2008. We did a Kaplan-Meier analysis of the cohort and used multivariate Cox regression analysis to identify significant predictors of survival.Results.Of the 22,394 dialysis patients studied, 303 (1.35%) had SLE. Hypertension and diabetes were the 2 most common comorbidities associated with dialysis for patients with and without SLE. After adjusting for age, sex, dialysis modality, and comorbidities, we found no significant survival difference between the 2 patient groups after 8 years of followup. Multivariate analysis showed that increased mortality in the patient group without SLE (p < 0.05) was associated with older age (≥ 45 years), male sex, initial choice of hemodialysis, diabetes mellitus, heart failure, coronary artery disease, cerebrovascular disease, and malignancy. In the patient group with SLE, independent predictors of mortality (p < 0.05) were older age (≥ 65 years), male sex, and diabetes mellitus.Conclusion.The longterm survival outcome was similar between patients with and without SLE who were on dialysis. The factors affecting patient mortality were not identical in these 2 groups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|