Event-related potentials following contraction of respiratory muscles in pre-term and full-term infants
| Autor: | Kimberley Whitehead, Laura Jones, Judith Meek, Maria Pureza Laudiano-Dray, Lorenzo Fabrizi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Evoked potential Diaphragm Somatosensory Electroencephalography 050105 experimental psychology Article Hiccup 03 medical and health sciences 0302 clinical medicine Physiology (medical) Medicine Humans 0501 psychology and cognitive sciences Respiratory system Proprioceptive Evoked Potentials Afferent Pathways Diaphragm contraction Proprioception medicine.diagnostic_test business.industry 05 social sciences Infant Newborn Afferent Trunk Sensory Systems Neurology Anesthesia Wakefulness Female Neurology (clinical) Sensorimotor Cortex medicine.symptom business 030217 neurology & neurosurgery Hiccups Infant Premature Muscle Contraction |
| Zdroj: | Clinical Neurophysiology |
| ISSN: | 1872-8952 1388-2457 |
| Popis: | Highlights • Diaphragm contraction in neonates evoked a sequence of three event-related potentials. • Hiccups can be encoded by the brain as early as ten weeks prior to average time of birth. • Hiccups – frequent in neonates – provide afferent input to the developing brain. Objective Involuntary isolated body movements are prominent in pre-term and full-term infants. Proprioceptive and tactile afferent feedback following limb muscle contractions is associated with somatotopic EEG responses. Involuntary contractions of respiratory muscles, primarily the diaphragm – hiccups – are also frequent throughout the human perinatal period during active behavioural states. Here we tested whether diaphragm contraction provides afferent input to the developing brain, as following limb muscle contraction. Methods In 13 infants on the neonatal ward (30–42 weeks corrected gestational age), we analysed EEG activity (18-electrode recordings in six subjects; 17-electrode recordings in five subjects; 16-electrode recordings in two subjects), time-locked to diaphragm contractions (n = 1316) recorded with a movement transducer affixed to the trunk. Results All bouts of hiccups occurred during wakefulness or active sleep. Each diaphragm contraction evoked two initial event-related potentials with negativity predominantly across the central region, and a third event-related potential with positivity maximal across the central region. Conclusions Involuntary contraction of the diaphragm can be encoded by the brain from as early as ten weeks prior to the average time of birth. Significance Hiccups – frequently observed in neonates – can provide afferent input to developing sensory cortices in pre-term and full-term infants. |
| Databáze: | OpenAIRE |
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