Very Early Response Evaluation by PET/MR in Patients with Lung Cancer—Timing and Feasibility
Autor: | Julie Lyng Forman, Barbara M. Fischer, S. Rasmussen, Junia Costa, Jens Benn Sørensen, Anders Olin, Thomas Levin Klausen, Helle Hjorth Johannesen, Andreas Kjaer, Johan Löfgren, Natasha Hemicke Langer, Seppo W. Langer, Adam E. Hansen |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
response evaluation
medicine.medical_treatment Clinical Biochemistry Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine non-small-cell lung carcinoma (NSCLC) medicine Effective diffusion coefficient In patient Positron emission Lung cancer FDG-PET Chemotherapy lcsh:R5-920 Lung business.industry diffusion weighted magnetic resonance imaging (DW-MRI) medicine.disease lung cancer medicine.anatomical_structure 030220 oncology & carcinogenesis Non small cell Stage iv business Nuclear medicine lcsh:Medicine (General) |
Zdroj: | Diagnostics, Vol 9, Iss 1, p 35 (2019) Diagnostics; Volume 9; Issue 1; Pages: 35 Langer, N H, Langer, S W, Johannesen, H H, Hansen, A E, Costa, J, Klausen, T L, Forman, J, Olin, A, Rasmussen, S H, Sørensen, J B, Löfgren, J, Kjær, A & Fischer, B M 2019, ' Very Early Response Evaluation by PET/MR in Patients with Lung Cancer : Timing and Feasibility ', Diagnostics, vol. 9, no. 1, 35 . https://doi.org/10.3390/diagnostics9010035 Diagnostics Langer, N H, Langer, S W, Johannesen, H H, Hansen, A E, Costa, J, Klausen, T L, Forman, J, Olin, A, Rasmussen, S H, Sørensen, J B, Löfgren, J, Kjær, A & Fischer, B M 2019, ' Very Early Response Evaluation by PET/MR in Patients with Lung Cancer-Timing and Feasibility ', Diagnostics (Basel, Switzerland), vol. 9, no. 1, 35 . https://doi.org/10.3390/diagnostics9010035 |
ISSN: | 2075-4418 |
Popis: | Purpose: With the increasing number of therapy options available for patients with lung cancer, early response evaluation is needed. We performed this pilot study to assess the feasibility of early, repeated Positron emission tomography-magnetic resonance (PET/MR), the impact of timing and the capability for response prediction in lung tumors during chemotherapy. Methods: Patients with stage IV non-small cell lung cancer referred for chemotherapy were prospectively recruited. Fluorine-18-Fluorodeoxyglucose(18F-FDG)-PET/MR scans were performed prior to, during and after the first or second cycle of chemotherapy. Primary tumors were defined on all scans and size, FDG-uptake and apparent diffusion coefficient (ADC) were measured. Early response was described over time and a Standard Linear Mixed Model was applied to analyze changes over time. Results: 45 FDG-PET/MR scans were performed in 11 patients. Whereas the overall changes measured by ADC did not change significantly, there was an overall significant decrease in FDG-uptake from pre to post treatment scans. There was no difference in the FDG-uptake measured 1 or 3 weeks after therapy, but uptake measured 2 weeks after therapy differed from measurements at week 3. Changes measured in patients scanned during the first treatment cycle appeared more pronounced than during the second cycle. Conclusions: This pilot study indicates that response evaluation shortly after initiation of chemotherapy appears concordant with later evaluation and probably more reliable than evaluation midway between cycles. Responses during or after the first cycle of chemotherapy rather than during subsequent cycles are likely to be more readily measured. |
Databáze: | OpenAIRE |
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