Macular Ganglion Cell-Inner Plexiform Layer as a Marker of Cognitive and Sensory Function in Midlife
| Autor: | Natascha Merten, Guan Hua Huang, Carla R. Schubert, Yanjun Chen, Lauren K Dillard, Adam J. Paulsen, Mary E. Fischer, Alex Pinto, Barbara E.K. Klein, Karen J. Cruickshanks |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Retinal Ganglion Cells THE JOURNAL OF GERONTOLOGY: Virtual Translational Section: Visionary Aging Aging medicine.medical_specialty Visual impairment Sensation Audiology Somatosensory system Logistic regression 03 medical and health sciences Cognition 0302 clinical medicine Hyposmia medicine Humans Macula Lutea Aged Aged 80 and over Retina business.industry Middle Aged Inner plexiform layer Ganglion Cross-Sectional Studies medicine.anatomical_structure 030221 ophthalmology & optometry Female sense organs Geriatrics and Gerontology medicine.symptom business Biomarkers Tomography Optical Coherence 030217 neurology & neurosurgery |
| Zdroj: | J Gerontol A Biol Sci Med Sci |
| ISSN: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/glaa135 |
| Popis: | Background Neurodegenerative diseases are public health challenges in aging populations. Early identification of people at risk for neurodegeneration might improve targeted treatment. Noninvasive, inexpensive screening tools are lacking but are of great potential. Optical coherence tomography (OCT) measures the thickness of nerve cell layers in the retina, which is an anatomical extension of the brain and might be indicative of common underlying neurodegeneration. We aimed to determine the association of macular ganglion cell-inner plexiform layer (mGCIPL) thickness with cognitive and sensorineural function in midlife. Method This cross-sectional study included 1,880 Beaver Dam Offspring Study participants (aged 27–93 years, mean 58) who participated in the 10-year follow-up examination. We assessed cognitive function and impairment, hearing sensitivity thresholds and impairment, central auditory processing, visual impairment, and olfactory impairment. We measured mGCIPL using the Cirrus 5000 HD-OCT Macular Cube Scan. Multivariable linear and logistic regression models adjusted for potential confounders were used to determine associations between mGCIPL thickness and cognitive and sensorineural functions, as well as for comparing participants with a thin mGCIPL (1 SD below average) to the remainder in those functions. Results Thinner mGCIPL was associated with worse cognitive function, worse central auditory function, and visual impairment. We found an association of mGCIPL thickness with hearing sensitivity in women only and no association with impairment in hearing, olfaction, and cognition. Results on the thin group comparisons were consistent. Conclusions mGCIPL thickness is associated with cognitive and sensorineural function and has the potential as a marker for neurodegeneration in middle-aged adults. |
| Databáze: | OpenAIRE |
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