Membrane nanotubes are ancient machinery for cell-to-cell communication and transport. Their interference with the immune system
| Autor: | Eszter Angéla Tóth, János Matkó |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell Intercellular transport Review Nanoparticle therapy Cell Communication Biology Interference (genetic) Cell Membrane Structures Models Biological General Biochemistry Genetics and Molecular Biology Immunomodulation 03 medical and health sciences 0302 clinical medicine Immune system Cell to cell communication medicine Animals Humans (Archae) Bacteria Membrane nanotubes Long-distance signaling Cells Cultured Simple (philosophy) Nanotubes Biological Transport Cytotoxic chemotherapy 030104 developmental biology medicine.anatomical_structure Prokaryotic Cells 030220 oncology & carcinogenesis Immune System General Agricultural and Biological Sciences Neuroscience Intracellular |
| Zdroj: | Biologia Futura |
| ISSN: | 2676-8607 |
| Popis: | Nanotubular connections between mammalian cell types came into the focus only two decades ago, when “live cell super-resolution imaging” was introduced. Observations of these long-time overlooked structures led to understanding mechanisms of their growth/withdrawal and exploring some key genetic and signaling factors behind their formation. Unbelievable level of multiple supportive collaboration between tumor cells undergoing cytotoxic chemotherapy, cross-feeding” between independent bacterial strains or “cross-dressing” collaboration of immune cells promoting cellular immune response, all via nanotubes, have been explored recently. Key factors and "calling signals" determining the spatial directionality of their growth and their overall in vivo significance, however, still remained debated. Interestingly, prokaryotes, including even ancient archaebacteria, also seem to use such NT connections for intercellular communication. Herein, we will give a brief overview of current knowledge of membrane nanotubes and depict a simple model about their possible “historical role”. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink