Parental age and childhood cancer risk: A Danish population-based registry study

Autor: Julia E. Heck, Zuelma A. Contreras, Jørn Olsen, Beate Ritz, Fei Yu, Johnni Hansen
Rok vydání: 2017
Předmět:
Parents
Male
Cancer Research
Pediatrics
Lymphoma
Epidemiology
Denmark
CHILDREN
FERTILITY TREATMENTS
0302 clinical medicine
Risk Factors
YOUNG-ADULTS
Medicine and Health Sciences
Medicine
2.1 Biological and endogenous factors
030212 general & internal medicine
DOWN-SYNDROME
Registries
Aetiology
Child
Cancer
Pediatric
education.field_of_study
Lymphoma
Non-Hodgkin
Hematology
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma
ADVANCED PATERNAL AGE
Oncology
Child
Preschool
030220 oncology & carcinogenesis
language
Public Health and Health Services
Female
Childhood cancer
Adult
medicine.medical_specialty
Pediatric Research Initiative
Adolescent
Offspring
Childhood Leukemia
Pediatric Cancer
Population
Oncology and Carcinogenesis
Non-Hodgkin
Wilms Tumor
Article
BIRTH CHARACTERISTICS
Danish
03 medical and health sciences
Paternal age
Rare Diseases
Parental age
ASSISTED REPRODUCTIVE TECHNOLOGY
SPORADIC HEREDITARY RETINOBLASTOMA
Humans
ACUTE-LEUKEMIA
Oncology & Carcinogenesis
Risk factor
WILMS-TUMOR
education
Preschool
Maternal age
business.industry
Prevention
Infant
Odds ratio
medicine.disease
language.human_language
Cancer registry
Logistic Models
Case-Control Studies
business
Demography
Zdroj: Contreras, Z A, Hansen, J, Ritz, B, Olsen, J, Yu, F & Heck, J E 2017, ' Parental age and childhood cancer risk : A Danish population-based registry study ', Cancer epidemiology, vol. 49, pp. 202-215 . https://doi.org/10.1016/j.canep.2017.06.010
Contreras, Zuelma A; Hansen, Johnni; Ritz, Beate; Olsen, Jorn; Yu, Fei; & Heck, Julia E. (2017). Parental age and childhood cancer risk: A Danish population-based registry study. Cancer epidemiology, 49, 202-215. UC Office of the President: Tobacco-Related Disease Research Program. Retrieved from: http://www.escholarship.org/uc/item/353648kv
DOI: 10.1016/j.canep.2017.06.010
Popis: Background: Though the association between parental age at child's birth and the risk of childhood cancer has been previously investigated, the evidence to date is inconclusive and scarce for rarer cancer types.Methods: Cancer cases (N = 5,856) were selected from all children born from 1968 to 2014 and diagnosed from 1968 to 2015 in Denmark at less than 16 years of age listed in the nationwide Danish Cancer Registry. Cases were individually matched to controls (1: 100) on sex and year of birth with a total of 585,594 controls randomly sampled from all live births in Denmark from the Danish Central Population Registry. Parental age at child's birth was extracted from the Central Population Registry. Conditional logistic regression models were used to estimate odds ratios for the association between parental age at child's birth and childhood cancer risk. Parental age was modeled as both categorical (referent group, parents aged 25-29) and continuous per 5-year increase in age.Results: Offspring of older mothers were at an increased risk of acute lymphoblastic leukemia [OR = 1.10, 95% CI: (1.02, 1.19) per 5-year increase in age]. Older maternal age (40+) increased the risk of non-Hodgkin lymphoma [OR = 1.96, 95%CI: (1.12, 3.43)]. The risk of Wilms' tumor also appeared elevated with older paternal age [OR = 1.11, 95% CI: (0.97, 1.28) per 5-year increment in age].Conclusion: Older parental age was a risk factor for various childhood cancers in Danish children. Further investigation of the biological and social factors that may be contributing to these associations is warranted. (C) 2017 Elsevier Ltd. All rights reserved.
Databáze: OpenAIRE
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