| Autor: |
Xiao-Tao He, Xuan Li, Meng Zhang, Bei-Min Tian, Li-Juan Sun, Chun-Sheng Bi, Dao-Kun Deng, Huan Zhou, Hong-Lei Qu, Chengtie Wu, Fa-Ming Chen |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Biomaterials. 283 |
| ISSN: |
1878-5905 |
| Popis: |
Recently, strategies that can target the underlying mechanisms of phenotype change to modulate the macrophage immune response from the standpoint of biological science have attracted increasing attention in the field of biomaterials. In this study, we printed a molybdenum-containing bioactive glass ceramic (Mo-BGC) scaffold as an immunomodulatory material. In a clinically relevant critical-size periodontal defect model, the defect-matched scaffold featured robust immunomodulatory activity, enabling long-term stable macrophage modulation and leading to enhanced regeneration of multiple periodontal tissues in canines. Further studies demonstrated that the regeneration-enhancing function of Mo-BGC scaffold was macrophage-dependent by using canines with host macrophage depletion. To investigate the role of Mo in material immunomodulation, in vitro investigations were performed and revealed that Mo-BGC powder extract, similar to MoO |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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