(S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one
| Autor: | Bartolo Gabriele, Nicola Della Ca, Mariangela Novello, Rossana Miliè, Raffaella Mancuso, Ida Ziccarelli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_element
carbonylation 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry Catalysis chemistry.chemical_compound cyclocarbonylation lcsh:Inorganic chemistry Physical and Theoretical Chemistry 010405 organic chemistry Organic Chemistry Substrate (chemistry) palladium lcsh:QD146-197 0104 chemical sciences Solvent oxazolidinones chemistry β-amino alcohols Yield (chemistry) Carbonylation Derivative (chemistry) Isopropyl Palladium |
| Zdroj: | Molbank, Vol 2018, Iss 3, p M1017 (2018) |
| ISSN: | 1422-8599 |
| Popis: | (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one has been synthesized for the first time by the enantiospecific oxidative carbonylation of commercially available (S)-2-amino-3-methyl-1,1-diphenylbutan-1-ol. The cyclocarbonylation reaction was carried out at 100 °C in 1,2-dimethoxyethane (DME) as the solvent for 15 h, under 20 atm of a 4:1 mixture of CO–air and in the presence of the catalytic system PdI2/KI (substrate:KI:PdI2 molar ratio = 100:10:1), to give the oxazolidinone derivative in 81% isolated yield. |
| Databáze: | OpenAIRE |
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