Neuroglobin and cytoglobin in search of their role in the vertebrate globin family
| Autor: | Sylvia Wystub, Anja Roesner, Michael C. Marden, Mark Haberkamp, Luc Moens, Sylvia Dewilde, Aaron Avivi, Bettina Weich, Angela Fago, Sigrid Saaler-Reinhardt, Martino Bolognesi, Christine Fuchs, Thomas Hankeln, Tilmann Laufs, Bettina Ebner, Eviatar Nevo, Marc Schmidt, Frank Gerlach, Roy E. Weber, Daniele de Sanctis, Thorsten Burmester, Stefan Reuss, Laurent Kiger |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Hemeproteins
Models Molecular Cell type Protein Conformation Molecular Sequence Data Neuroglobin Nerve Tissue Proteins Biochemistry Inorganic Chemistry chemistry.chemical_compound Oxygen homeostasis Animals Humans Globin Amino Acid Sequence Phylogeny Regulation of gene expression Chemistry Cytoglobin Molecular biology Cell biology Globins Myoglobin Gene Expression Regulation Sequence Alignment Function (biology) |
| Zdroj: | Hankeln, T, Ebner, B, Fuchs, C, Gerlach, F, Haberkamp, M, Laufs, T L, Roesner, A, Schmidt, M, Weich, B, Wystub, S, Saaler-Reinhardt, S, Reuss, S, Bolognesi, M, De Sanctis, D, Marden, M C, Kiger, L, Moens, L, Dewilde, S, Nevo, E, Avivi, A, Weber, R E, Fago, A & Burmester, T 2005, ' Neuroglobin and cytoglobin in search of their role in the vertebrate globin family ', Journal of Inorganic Biochemistry, vol. 99, pp. 110-119 . Journal of inorganic biochemistry Aarhus University |
| ISSN: | 0162-0134 |
| Popis: | Neuroglobin and cytoglobin are two recent additions to the family of heme-containing respiratory proteins of man and other vertebrates. Here, we review the present state of knowledge of the structures, ligand binding kinetics, evolution and expression patterns of these two proteins. These data provide a first glimpse into the possible physiological roles of these globins in the animal's metabolism. Both, neuroglobin and cytoglobin are structurally similar to myoglobin, although they contain distinct cavities that may be instrumental in ligand binding. Kinetic and structural studies show that neuroglobin and cytoglobin belong to the class of hexa-coordinated globins with a biphasic ligand-binding kinetics. Nevertheless, their oxygen affinities resemble that of myoglobin. While neuroglobin is evolutionarily related to the invertebrate nerve-globins, cytoglobin shares a more recent common ancestry with myoglobin. Neuroglobin expression is confined mainly to brain and a few other tissues, with the highest expression observed in the retina. Present evidence points to an important role of neuroglobin in neuronal oxygen homeostasis and hypoxia protection, though other functions are still conceivable. Cytoglobin is predominantly expressed in fibroblasts and related cell types, but also in distinct nerve cell populations. Much less is known about its function, although in fibroblasts it might be involved in collagen synthesis. |
| Databáze: | OpenAIRE |
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