Accuracies of fecal calprotectin, lactoferrin, M2-pyruvate kinase, neopterin and zonulin to predict the response to infliximab in ulcerative colitis
| Autor: | Gilles Boschetti, Patricia Ferrari, Stéphane Nancey, Xavier Hébuterne, Bernard Flourié, Jocelyne Drai, Anne-Claire Frin, Jérôme Filippi |
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| Přispěvatelé: | Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL) |
| Rok vydání: | 2016 |
| Předmět: |
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[SDV]Life Sciences [q-bio] Kaplan-Meier Estimate Gastroenterology chemistry.chemical_compound Feces 0302 clinical medicine Induction therapy Medicine Prospective Studies biology Lactoferrin Remission Induction Zonulin Neopterin Middle Aged Ulcerative colitis 3. Good health 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female France medicine.drug Adult medicine.medical_specialty Cholera Toxin Adolescent Pyruvate Kinase 03 medical and health sciences Young Adult Gastrointestinal Agents Internal medicine Humans Protein Precursors Aged Hepatology Haptoglobins business.industry medicine.disease Infliximab chemistry ROC Curve Immunology biology.protein Colitis Ulcerative Calprotectin business Leukocyte L1 Antigen Complex Biomarkers |
| Zdroj: | Digestive and Liver Disease Digestive and Liver Disease, WB Saunders, 2017, 49 (1), pp.11-16. ⟨10.1016/j.dld.2016.09.001⟩ |
| ISSN: | 1878-3562 1590-8658 |
| Popis: | International audience; BACKGROUND: Fecal markers might predict the response to anti-TNFalpha in ulcerative colitis (UC). AIMS: To compare the performance of fecal calprotectin (fCal), lactoferrin (fLact), M2-PK (fM2-PK), neopterin (fNeo), and zonulin (fZon) to predict the response to therapy in active UC patients. METHODS: Disease activity from 31 consecutive patients with an active UC, treated with infliximab (IFX) was assessed by the Mayo score at baseline and at week 14 and by the partial Mayo score at W52 and stool samples collected for fecal marker measurements at W0, W2, and W14. RESULTS: At W14, 19 patients (61%) were responders to IFX induction. The median levels of fCal, fLact and fM2-PK drop dramatically from baseline to W14 in clinical responders. At W2, fM2-PK, fLact and fCal levels predicted accurately the response to IFX induction. At W14, fLact, fCal, and fM2-PK were individually reliable markers to predict sustained response at W52. The performances of fNeo and fZon were weaker in this setting. CONCLUSIONS: The performance of fM2-PK at W2 to predict response to induction therapy with IFX was superior to that of fLact and fCal, whereas monitoring fLact was the best tool to predict adequately the course of the disease at one year under maintenance IFX in UC. |
| Databáze: | OpenAIRE |
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