Helicobacter pyloriand gut microbiota modulate energy homeostasis prior to inducing histopathological changes in mice
| Autor: | Jamuna Vadivelu, Sven Pettersson, Qian Hui Poh, Ralph M. Bunte, Kher Hsin Chiow, Arlaine Anne Amoyo, Yalda Khosravi, Tuan Lin Tan, Shih Wee Seow, Mun Fai Loke, Ignatius Mario Doli Sentosa, Whye Yen Wong |
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| Rok vydání: | 2016 |
| Předmět: |
Leptin
0301 basic medicine Microbiology (medical) medicine.medical_specialty Enteroendocrine cell Gut flora digestive system Microbiology Energy homeostasis Helicobacter Infections Mice 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Gastric mucosa Animals Humans Insulin Peptide YY Addenda Helicobacter pylori biology digestive oral and skin physiology Gastroenterology bacterial infections and mycoses biology.organism_classification Ghrelin Gastrointestinal Microbiome 030104 developmental biology Infectious Diseases medicine.anatomical_structure Endocrinology Gastric Mucosa Immunology 030211 gastroenterology & hepatology Energy Metabolism Hormone |
| Zdroj: | Gut Microbes. 7:48-53 |
| ISSN: | 1949-0984 1949-0976 |
| DOI: | 10.1080/19490976.2015.1119990 |
| Popis: | Helicobacter pylori have been shown to influence physiological regulation of metabolic hormones involved in food intake, energy expenditure and body mass. It has been proposed that inducing H. pylori-induced gastric atrophy damages hormone-producing endocrine cells localized in gastric mucosal layers and therefore alter their concentrations. In a recent study, we provided additional proof in mice under controlled conditions that H. pylori and gut microbiota indeed affects circulating metabolic gut hormones and energy homeostasis. In this addendum, we presented data from follow-up investigations that demonstrated H. pylori and gut microbiota-associated modulation of metabolic gut hormones was independent and precedes H. pylori-induced histopathological changes in the gut of H. pylori-infected mice. Thus, H. pylori-associated argumentation of energy homeostasis is not caused by injury to endocrine cells in gastric mucosa. |
| Databáze: | OpenAIRE |
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