ADMA concentration changes across the menstrual cycle and during oral contraceptive use: the Cardiovascular Risk in Young Finns Study
| Autor: | Tomi Laitinen, Nonna Heiskanen, Mika Kähönen, Olli T. Raitakari, Kari Punnonen, Seppo Heinonen, Heli Saarelainen, Georg Alfthan, Tiina Lyyra-Laitinen, Markus Juonala, Reijo Laaksonen, Pirjo Valtonen, Jorma Viikari |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Brachial Artery Endocrinology Diabetes and Metabolism media_common.quotation_subject Population Luteal phase Arginine Menstruation Young Adult chemistry.chemical_compound Endocrinology Risk Factors Internal medicine medicine.artery Follicular phase medicine Humans Prospective Studies Brachial artery education Finland Menstrual Cycle Menstrual cycle media_common education.field_of_study Progesterone Congeners business.industry Estrogens General Medicine Atherosclerosis Vasodilation Menstrual cycle phase C-Reactive Protein chemistry Creatinine Female business Asymmetric dimethylarginine Contraceptives Oral |
| Zdroj: | European Journal of Endocrinology. 162:259-265 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje-09-0658 |
| Popis: | ObjectiveThe aim of this study was to evaluate changes in the nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) levels during different menstrual cycle phases in young adult women with or without oral contraceptive (OC) use.Design and methodsThe subjects (n=1079) originated from a large population-based, prospective cohort study conducted in Finland. Plasma ADMA, symmetric dimethylarginine (SDMA), l-arginine, C-reactive protein, creatinine, and brachial artery flow-mediated dilatation (FMD) were measured. The use of OCs and menstrual cycle phase were determined from a questionnaire.ResultsIn non-OC users, ADMA (P=0.017), l-arginine (P=0.002), and ADMA/SDMA ratio (PPl-arginine concentrations (PP=0.013) than in the follicular phase.ConclusionWe observed that the circulating ADMA concentration varies across the menstrual cycle in young women not using OCs, and women on OCs displayed significantly lower circulating ADMA concentrations than non-OC users, though this was not the case with POP contraception. |
| Databáze: | OpenAIRE |
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