Sulfobacins A and B, Novel von Willebrand Factor Receptor Antagonists. II. Structural Elucidaffon
| Autor: | Yoshiko Itezono, Kazuteru Yokose, Yumiko Nakamura, Tomoko Satoh, Tsutomu Kamiyama, Takayuki Umino |
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| Rok vydání: | 1995 |
| Předmět: |
Pharmacology
Bacterial gliding Molecular Structure biology Chemistry Stereochemistry Chemical structure Receptors Cell Surface Stereoisomerism Platelet Membrane Glycoproteins Chryseobacterium biology.organism_classification Sulfonolipids Alkanesulfonic Acids Von Willebrand factor Drug Discovery biology.protein Cell envelope Receptor Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | The Journal of Antibiotics. 48:929-936 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.48.929 |
| Popis: | Sulfobacins A and B are novel von Willebrand factor (vWF) receptor antagonists produced by Chryseobacterium sp. NR 2993. The structures of sulfobacins A and B have been determined to be (2R,3R)-3-hydroxy-2-[(R)-3-hydroxy-15-methylhexadecanamido]-15- methylhexadecanesulfonic acid and (2R,3R)-3-hydroxy-15-methyl-2-[13-methyltetradecanamido]- hexadecanesulfonic acid, respectively, by various 2D NMR experiments and by methanolysis. The absolute configurations of the sulfobacins were determined by a modified MOSHER's method. The structures are related to sulfonolipids, major components of the cell envelope of gliding bacteria of the genus Cytophaga. |
| Databáze: | OpenAIRE |
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