Model Studies of the Iron-Catalysed Haber-Weiss Cycle and the Ascorbate-Driven Fenton Reaction
| Autor: | M J Burkitt, B C Gilbert |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Nitrilotriacetic Acid
inorganic chemicals Xanthine Oxidase Phytic Acid Stereochemistry Iron Succinic Acid Ascorbic Acid Hydroxylation Ferric Compounds Xanthine Biochemistry Citric Acid Catalysis chemistry.chemical_compound Hydroxides Chelation Citrates Ferrous Compounds Edetic Acid Hydroxyl Radical Electron Spin Resonance Spectroscopy Nitrilotriacetic acid Succinates Pentetic Acid Ascorbic acid Combinatorial chemistry Salicylates chemistry Succinic acid Xanthines Hydroxyl radical Salicylic Acid Citric acid Oxidation-Reduction |
| Zdroj: | Free Radical Research Communications. 10:265-280 |
| ISSN: | 8755-0199 |
| DOI: | 10.3109/10715769009149895 |
| Popis: | Complementary hydroxylation assays and stopped-flow e.s.r. techniques have been employed in the investigation of the effect of various iron chelators (of chemical, biological and clinical importance) on hydroxyl-radical generation via the Haber-Weiss cycle and the ascorbate-driven Fenton reaction. Chelators have been identified which selectively promote or inhibit various reactions involved in hydroxyl-radical generation (for example, NTA and EDTA promote all the reactions of both the Haber-Weiss cycle and the ascorbate-driven Fenton reaction, whereas DTPA and phytate inhibit the recycling of iron in these reactions). The biological chelators succinate and citrate are shown to be relatively poor catalysts of the Haber-Weiss cycle, whereas they are found to be effective catalysts of .OH generation in the ascorbate-driven Fenton reaction. It is also suggested that continuous redox-cycling reactions between iron, oxygen and ascorbate may represent an important mechanism of cell death in biological systems. |
| Databáze: | OpenAIRE |
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