Nitrosative stress and pharmacological modulation of heart failure

Autor: Richard Schulz, Pal Pacher, Csaba Szabó, Lucas Liaudet
Rok vydání: 2005
Předmět:
Poly(ADP-ribose) Polymerase Inhibitors
Pharmacology
Matrix metalloproteinase
Nitric Oxide
Toxicology
medicine.disease_cause
Poly (ADP-Ribose) Polymerase Inhibitor
Article
Nitric oxide
chemistry.chemical_compound
Peroxynitrous Acid
medicine
Humans
Enzyme Inhibitors
Heart Failure
biology
Chemistry
Superoxide
Enzyme Activation Enzyme Inhibitors/therapeutic use Heart Failure
Congestive/*drug therapy/*metabolism Humans Matrix Metalloproteinase 2/metabolism Matrix Metalloproteinase 9/metabolism Nitric Oxide/*physiology Nitric Oxide Synthase/physiology *Oxidative Stress Peroxynitrous Acid/toxicity Poly(ADP-ribose) Polymerases/antagonists & inhibitors/metabolism
Enzyme Activation
Nitric oxide synthase
Oxidative Stress
Peroxynitrous acid
Matrix Metalloproteinase 9
Biochemistry
biology.protein
Matrix Metalloproteinase 2
Nitric Oxide Synthase
Poly(ADP-ribose) Polymerases
Peroxynitrite
Oxidative stress
Zdroj: Trends in Pharmacological Sciences, vol. 26, no. 6, pp. 302-10
ISSN: 0165-6147
DOI: 10.1016/j.tips.2005.04.003
Popis: Dysregulation of nitric oxide (NO) and increased oxidative and nitrosative stress are implicated in the pathogenesis of heart failure. Peroxynitrite is a reactive oxidant that is produced from the reaction of nitric oxide with superoxide anion and impairs cardiovascular function through multiple mechanisms, including activation of matrix metalloproteinases (MMPs) and nuclear enzyme poly(ADP-ribose) polymerase (PARP). Recent studies suggest that the neutralization of peroxynitrite or pharmacological inhibition of MMPs and PARP are promising new approaches in the experimental therapy of various forms of myocardial injury. In this article, the role of nitrosative stress and downstream mechanisms, including activation of MMPs and PARP, in various forms of heart failure are discussed and novel emerging therapeutic strategies offered by neutralization of peroxynitrite and inhibition of MMPs and PARP in these pathophysiological conditions are reviewed.
Databáze: OpenAIRE
Externí odkaz: