Secondary mutations in t(4;11) leukemia patients
| Autor: | A Bursen, Rolf Marschalek, Theodor Dingermann, C Prelle |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Cancer Research
Chromosomal translocation Biology medicine.disease_cause Translocation Genetic Fusion gene hemic and lymphatic diseases medicine Humans Letter to the Editor neoplasms Mutation Acute leukemia Leukemia Chromosomes Human Pair 11 Histone-Lysine N-Methyltransferase Hematology medicine.disease Fusion protein Genes ras fms-Like Tyrosine Kinase 3 Oncology Fms-Like Tyrosine Kinase 3 Immunology Myeloid-Lymphoid Leukemia Protein Chromosomes Human Pair 4 |
| Zdroj: | Leukemia |
| ISSN: | 1476-5551 0887-6924 |
| DOI: | 10.1038/leu.2012.365 |
| Popis: | MLL rearrangements are a genetic hallmark of acute leukemia patients, which exhibit a particular poor outcome. To date, more than 70 MLL rearrangements have been described at the molecular level.1 For the most frequently diagnosed MLL rearrangements, for example, AF4-MLL, MLL-AF9, MLL-AF10 or MLL-ENL, it has been shown that these fusion proteins are sufficient for acute leukemia onset in murine model systems.2 However, these models had a latency time of 4–12 months for the disease phenotype to become overt. This argues in favor of pre-leukemic clones that carry the fusion genes, but need, in addition, complementing mutations to develop a malignant disease. |
| Databáze: | OpenAIRE |
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