Pneumotoxic effects of radioactive dust (RD) from a Nuclear Power Plant in Kozloduy, Bulgaria
| Autor: | Veneta Shopova, Violeta Dancheva, Pencho Salovsky |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Pathology medicine.medical_specialty Antioxidant medicine.medical_treatment Pharmacology Superoxide dismutase chemistry.chemical_compound Occupational Exposure Lactate dehydrogenase Animals Medicine Rats Wistar Bulgaria chemistry.chemical_classification biology medicine.diagnostic_test business.industry Glutathione peroxidase Public Health Environmental and Occupational Health Rats respiratory tract diseases Bronchoalveolar lavage chemistry Air Pollutants Radioactive Catalase Toxicity biology.protein Alkaline phosphatase Lipid Peroxidation business Bronchoalveolar Lavage Fluid Power Plants |
| Zdroj: | American Journal of Industrial Medicine. 38:639-643 |
| ISSN: | 1097-0274 0271-3586 |
| DOI: | 10.1002/1097-0274(200012)38:6<639::aid-ajim4>3.0.co;2-n |
| Popis: | BACKGROUND Airborne radioactive particles isolated from the reactor halls of nuclear power plants are a potential risk to the respiratory system of the working staff. Such radioactive dust (RD) from the Nuclear Power Plant, Kozloduy, Bulgaria was investigated. METHODS The RD was administered intratracheally to 60 male Wistar rats as an aqueous suspension and the biological effects are estimated, using sensitive biological markers in bronchoalveolar lavage fluid (BALF) and important parameters of the pulmonary antioxidant defense. RESULTS The results obtained show that RD increases the total cell number, the activities of the lactate dehydrogenase and alkaline phosphatase as well as the protein content in BALF. The activities of superoxide dismutase and catalase in lung homogenate are decreased while activity of the glutathione peroxidase and the content of non-protein sulfhydrils is elevated. CONCLUSIONS It is concluded that the RD causes transitory toxic effect on lung tissue and changes the correlation between the elements of the pulmonary antioxidative defense. |
| Databáze: | OpenAIRE |
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