Acute Hepatitis in the DRESS Syndrome
| Autor: | Ana Maria de Oliveira, Rita Carvalho, Alexandra Martins, Jorge Reis |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Clinical Case Sulfasalazine Maculopapular rash medicine Eosinophilia Sulfasalazine/adverse effects Síndrome de Hipersensibilidade a Medicamentos Doença Hepática Induzida por Medicamentos 030212 general & internal medicine lcsh:RC799-869 Hepatitis business.industry Falência Hepática Aguda/induzida quimicamente Gastroenterology Drug-Induced Liver Injury medicine.disease Dermatology Rash Sulfassalazina/efeito adverso Surgery Diarrhea Drug Hypersensitivity Syndrome Liver Failure Acute/chemically induced Vomiting lcsh:Diseases of the digestive system. Gastroenterology medicine.symptom business medicine.drug |
| Zdroj: | GE Portuguese Journal of Gastroenterology GE: Portuguese Journal of Gastroenterology, Vol 23, Iss 6, Pp 304-308 (2016) |
| ISSN: | 2341-4545 |
| DOI: | 10.1016/j.jpge.2016.06.001 |
| Popis: | Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe, idiosyncratic reaction characterized by diffuse maculopapular rash, facial edema, lymphadenopathy, fever, eosinophilia and/or other leukocyte abnormalities, and involvement of internal organs as liver, kidney, heart and lung.Diagnosing this entity is specifically complicated due to the multiplicity of organs involved. DRESS syndrome must be recognized promptly and the causative drug withdrawn in order to improve patient outcomes. Indeed, it is a potentially life-threatening condition, with a reported mortality between 5 and 20%.We describe a case of a 22-year old woman admitted to our hospital with acute diffuse, pruritic rash associated with crampy abdominal pain, vomiting, diarrhea and fever three weeks after starting sulfasalazine therapy.Initially, laboratory parameters revealed normal white blood cell count and normal liver enzymes, but during hospitalization, eosinophilia developed and liver enzymes, including transaminases and cholestatic parameters, dramatically increased. The diagnostic of DRESS syndrome was made and sulfasalazine was withdrawn and as there were signs of disease severity, systemic corticotherapy was initiated, with gradually improvement of the rash and symptoms resolution.The patient was discharged home after thirty days of hospitalization. |
| Databáze: | OpenAIRE |
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