The effects of fatigue, depression and the level of disability on the health-related quality of life of glatiramer acetate-treated relapsing-remitting patients with multiple sclerosis in Hungary
| Autor: | Sámuel Komoly, Zsanett Fricska-Nagy, László Vécsei, Krisztina Bencsik, Csilla Rozsa, Judit Füvesi, Gyula Lencsés, Gábor Jakab, Zita Jobbágy, Tünde Csépány |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Disease Klinikai orvostudományok 03 medical and health sciences Disability Evaluation 0302 clinical medicine Multiple Sclerosis Relapsing-Remitting Quality of life Prevalence Medicine Humans 030212 general & internal medicine Glatiramer acetate Depression (differential diagnoses) Fatigue Psychiatric Status Rating Scales Hungary business.industry Depression Multiple sclerosis Beck Depression Inventory Cognition General Medicine Glatiramer Acetate Orvostudományok medicine.disease Sexual dysfunction Neurology Physical therapy Linear Models Quality of Life Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Immunosuppressive Agents medicine.drug |
| Popis: | Background The common symptoms of multiple sclerosis are fatigue, depression, cognitive dysfunction, pain and sexual dysfunction, which influence the health-related quality of life of the patients. Objective We aimed to determine the correlations between the health-related quality of life, the level of disability, fatigue and depression in glatiramer acetate-treated patients with multiple sclerosis in Hungary. Methods The Hungarian versions of the Multiple Sclerosis Quality of Life-54, Fatigue Impact Scale and Beck Depression Inventory questionnaires were completed by 428 relapsing-remitting multiple sclerosis patients treated with glatiramer acetate from 19 Hungarian centers. Results The prevalence of fatigue was found to be 62.4%. The prevalence of depression was lower (13.4%) than that described in previous studies (36–54%) among patients with multiple sclerosis. Significant differences in the health-related quality of life were found between fatigued and non-fatigued patients. The level of disability, fatigue, depression and the duration of the disease correlated significantly with the quality of life. However, linear regression analysis indicated that the quality of life was predicted by the level of disability, depression, social and cognitive fatigue, but not by physical fatigue. Conclusions Decreasing the disease activity in multiple sclerosis with immunomodulatory therapy, together with improvements of the diagnostics and treatment of the accompanying depression and fatigue are of high priority to improve the health-related quality of life of patients with multiple sclerosis. |
| Databáze: | OpenAIRE |
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