Carboplatin in Combination with Epirubicin and Cyclophosphamide in Patients with Advanced Ovarian Cancer: A phase II study
| Autor: | L G Friberg, Håkan Andersson, O Johansson, M Akesson, R. Westberg, György Horvath |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Reoperation medicine.medical_specialty Neoplasm Residual Cyclophosphamide Vomiting medicine.medical_treatment Phases of clinical research Gastroenterology Carboplatin chemistry.chemical_compound Internal medicine Antineoplastic Combined Chemotherapy Protocols Ambulatory Care Humans Medicine Radiology Nuclear Medicine and imaging Antineoplastic Agents Alkylating Survival rate Aged Epirubicin Neoplasm Staging Ovarian Neoplasms Laparotomy Chemotherapy Antibiotics Antineoplastic business.industry Carcinoma Remission Induction Leukopenia Hematology General Medicine Middle Aged Thrombocytopenia Chemotherapy regimen Surgery Survival Rate Oncology chemistry Toxicity Disease Progression Female business Follow-Up Studies medicine.drug |
| Zdroj: | Acta Oncologica. 34:821-827 |
| ISSN: | 1651-226X 0284-186X |
| DOI: | 10.3109/02841869509127192 |
| Popis: | Seventy-one patients with epithelial ovarian cancer stage III (n = 56) or IV (n = 15) were treated with carboplatin 300 mg/m2, epirubicin 50 mg/m2 and cyclophosphamide 400 mg/m2 every fourth week. Patients clinically free of tumour after six courses (n = 58) underwent a second-look laparotomy. Seventeen patients were microscopically tumour-free (24% of all) and an additional 10 (14%) had only microscopic cancer. Median time to progression was 19 months. The median survival was 33 months and the estimated 5-year survival 27%. The toxicity was mainly haematological, with leukopenia WHO grade 3-4 seen in 88% and thrombocytopenia grade 3-4 in 42% of the patients. The gastrointestinal toxicity was mild and no renal toxicity was seen. This chemotherapy regimen was effective with acceptable toxicity and could be given on an out-patient basis. The possibility of increasing the efficacy and decreasing the toxicity was discussed. |
| Databáze: | OpenAIRE |
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