The dose-response relationship for cardiovascular disease is not necessarily linear
| Autor: | Marina Ernst, Matthias Hartmann, Uwe Schneider |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
Organs at Risk medicine.medical_specialty Dose-response curves lcsh:R895-920 medicine.medical_treatment Irradiated Volume Breast Neoplasms NTCP Disease lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Breast cancer Bio-physical modeling Internal medicine Epidemiology medicine Humans Radiology Nuclear Medicine and imaging 030212 general & internal medicine Radiation Injuries business.industry Radiotherapy Dosage lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cardiovascular disease medicine.disease Surgery Radiation therapy Dose–response relationship Oncology Cardiovascular Diseases 030220 oncology & carcinogenesis Relative risk Commentary Cardiology Female Radiotherapy Intensity-Modulated Complication business |
| Zdroj: | Radiation Oncology (London, England) Radiation Oncology, Vol 12, Iss 1, Pp 1-4 (2017) |
| ISSN: | 1748-717X |
| Popis: | The probability for a complication after radiotherapy is usually a function of dose and volume in the organ or tissue of interest. In most epidemiological studies the risk for a complication is stratified in terms of dose, but not irradiated volume. We show that the obtained risk cannot generally be applied to radiotherapy patients.The epidemiological data of Darby et al. (N Engl J Med 368:2527, 2013) who found a linear relationship between the excess relative risk of major coronary events as function of mean heart dose in patients treated with tangential breast irradiation are analyzed. We have used the relative seriality model for a partly irradiated heart (“a lot to a little”) which models radiation therapy using two tangential fields. The relative seriality model was then used to predict NTCP of cardiovascular disease for a homogenously irradiated heart (“a little to a lot”). The relative seriality model was fitted to the data of Darby et al. (N Engl J Med 368:2527, 2013) for tangential breast irradiation. For the situation “a little to a lot” it was found that the dose-response relationship is sigmoidal and contradicts the findings of Darby et al. (N Engl J Med 368:2527, 2013). It was shown in this work that epidemiological studies which predict a linear dose-response relationship for cardiovascular disease can be reproduced by bio-physical models for normal tissue complication. For irradiation situations which were not included in the epidemiological studies, e.g. a homogenous irradiation of the heart (“a little to a lot”) the dose-response curve can be different. This could have consequences whether or not IMRT should be used for treating breast cancer. We believe that the results of epidemiological studies should not be generally used to predict normal tissue complications. It is better to use such data to optimize bio-physical models which can then be applied (with caution) to general treatment situations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|