Primate antibodies to components of the human immune system
| Autor: | E. Harfeldt, Edwin L. Kaplan, P. Ehrlich, P. Lake, L. Östberg, L. Lögdberg, D. Dottavio, M. Drelich, H. Gunn |
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| Rok vydání: | 1994 |
| Předmět: |
Primates
Pan troglodytes medicine.drug_class T-Lymphocytes Enzyme-Linked Immunosorbent Assay Monoclonal antibody Immunoglobulin G law.invention Immune system Antigens CD law biology.animal medicine Animals Humans Immunization Schedule General Veterinary biology Tumor Necrosis Factor-alpha Antibodies Monoclonal Granulocyte-Macrophage Colony-Stimulating Factor Hominidae Receptors Interleukin-2 Flow Cytometry Macaca mulatta Virology Recombinant Proteins Immunization Antibody Formation CD4 Antigens Immunology biology.protein Recombinant DNA Cytokines Animal Science and Zoology Tumor necrosis factor alpha Antibody Papio Baboon |
| Zdroj: | Journal of Medical Primatology. 23:285-297 |
| ISSN: | 0047-2565 |
| DOI: | 10.1111/j.1600-0684.1994.tb00286.x |
| Popis: | The feasibility to raise nonhuman primate antibodies against selected components of the human immune system was tested. The immunogens were whole cells (human T lymphocytes) or purified, recombinant human proteins (cytokines: TNF alpha or GM-CSF; soluble forms of cell surface antigens: sCD4 or sCD25). Significant immunizations, yielding functionally relevant antibodies, were readily achieved in rhesus monkeys, but, not surprisingly, may be less frequent in chimpanzees. The results suggest a general strategy for production of therapeutically useful MAB. |
| Databáze: | OpenAIRE |
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