Toward a unified theory of aging and regeneration
| Autor: | Dana Larocca, Mike West, Aubrey D. N. J. de Grey, Hal Sternberg, Karen B. Chapman, Nafees N. Malik, Ivan Labat, Jeffrey R. Janus |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Aging
0303 health sciences Embryology Telomerase Regeneration (biology) Biomedical Engineering Biology Models Biological Embryonic stem cell Cell biology 03 medical and health sciences 0302 clinical medicine Pleiotropy (drugs) Neoplasms Humans Regeneration Epigenetics Induced pluripotent stem cell Reprogramming 030217 neurology & neurosurgery PI3K/AKT/mTOR pathway 030304 developmental biology |
| Zdroj: | Regenerative Medicine. 14:867-886 |
| ISSN: | 1746-076X 1746-0751 |
| DOI: | 10.2217/rme-2019-0062 |
| Popis: | Growing evidence supports the antagonistic pleiotropy theory of mammalian aging. Accordingly, changes in gene expression following the pluripotency transition, and subsequent transitions such as the embryonic–fetal transition, while providing tumor suppressive and antiviral survival benefits also result in a loss of regenerative potential leading to age-related fibrosis and degenerative diseases. However, reprogramming somatic cells to pluripotency demonstrates the possibility of restoring telomerase and embryonic regeneration pathways and thus reversing the age-related decline in regenerative capacity. A unified model of aging and loss of regenerative potential is emerging that may ultimately be translated into new therapeutic approaches for establishing induced tissue regeneration and modulation of the embryo-onco phenotype of cancer. |
| Databáze: | OpenAIRE |
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