INTRABEAM intraoperative radiotherapy combined with portal vein infusion chemotherapy for treating hepatocellular carcinoma with portal vein tumor thrombus

Autor: Zili Shao, Xiaodong Song, Huihong Liang, Yong He, Menling Han
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
medicine.medical_specialty
Carcinoma
Hepatocellular
Intraoperative radiotherapy
Organoplatinum Compounds
Hepatocellular carcinoma
Portal vein infusion chemotherapy
medicine.medical_treatment
Leucovorin
lcsh:Surgery
Case Report
030218 nuclear medicine & medical imaging
03 medical and health sciences
Folinic acid
0302 clinical medicine
FOLFOX
Antineoplastic Combined Chemotherapy Protocols
medicine
Hepatectomy
Humans
Portal vein tumor thrombus
Intraoperative radiation therapy
Aged
Retrospective Studies
Thrombectomy
Venous Thrombosis
Intraoperative Care
Portal Vein
business.industry
Liver Neoplasms
General Medicine
lcsh:RD1-811
medicine.disease
Combined Modality Therapy
digestive system diseases
Oxaliplatin
Surgery
Regimen
Fluorouracil
030220 oncology & carcinogenesis
Radiotherapy
Adjuvant
business
medicine.drug
Zdroj: BMC Surgery, Vol 20, Iss 1, Pp 1-6 (2020)
BMC Surgery
ISSN: 1471-2482
DOI: 10.1186/s12893-020-00836-2
Popis: BackgroundPortal vein tumor thrombus (PVTT) is common in hepatocellular carcinoma (HCC). Recent studies indicate that more aggressive treatments, including surgical resection or locoregional treatment, may benefit selected HCC patients with PVTT. External radiation therapy and infusion chemotherapy were found to achieve good outcomes; however, the use of low-energy x-ray radiation system (INTRABEAM), intraoperative radiation therapy, and portal vein infusion chemotherapy for PVTT has not been reported.Case summaryWe present a case of HCC with PVTT. The patient underwent hemihepatectomy and thrombectomy along with intraoperative radiotherapy (IORT) using a portable INTRABEAM radiation system. Subsequently, to treat PVTT, portal vein infusion chemotherapy with FOLFOX (leucovorin [Folinic acid], fluorouracil, and oxaliplatin) regimen was administered. There were no obvious post-operative complications. After 20 months follow-up period, no obvious tumor recurrence had been observed, and PVTT gradually disappeared completely.ConclusionsIORT using the INTRABEAM radiation system combined with portal vein infusion chemotherapy is promising for select patients with PVTT.
Databáze: OpenAIRE
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