Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations
| Autor: | J. M. Palva, Tiina Paunio, Elvira Brattico, Jaana Simola, Felix Siebenhühner, Satu Palva, Katri Kantojarvi, V. Myrov |
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| Přispěvatelé: | University of Helsinki, Department of Neuroscience and Biomedical Engineering, University of Bari, University of Glasgow, Aalto-yliopisto, Aalto University, Department of Education, Neuroscience Center, BioMag Laboratory, Helsinki Institute of Life Science HiLIFE, SLEEPWELL Research Program, Clinicum, HUS Helsinki and Uusimaa Hospital District, HUS Psychiatry, Department of Psychiatry, Matias Palva / Principal Investigator, Biosciences, Faculty Common Matters (Faculty of Biology and Environmental Sciences) |
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
MEG Multidisciplinary medicine.diagnostic_test Dynamics (mechanics) 3112 Neurosciences Cognitive neuroscience Magnetoencephalography Biology COMT Biological sciences 03 medical and health sciences BDNF 0302 clinical medicine Neurotrophic factors Synchronization (computer science) medicine BRAIN OSCILLATIONS Bdnf polymorphism GENETIC POLYMORPHISMS Neuroscience 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Simola, J, Siebenhühner, F, Myrov, V, Kantojärvi, K, Paunio, T, Palva, J M, Brattico, E & Palva, S 2022, ' Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations ', iScience, vol. 25, no. 9, 104985 . https://doi.org/10.1016/j.isci.2022.104985 |
| DOI: | 10.1101/2021.11.16.468778 |
| Popis: | SummaryNeuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. However, the genetic underpinnings of oscillatory dynamics have remained poorly understood. We recorded resting-state magnetoencephalography (MEG) from 82 healthy participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in Catechol-O-methyltransferase (COMT) Val158Met and brain-derived neurotrophic factor (BDNF) Val66Met. Both COMT and BDNF polymorphisms influenced local oscillation amplitudes and their long-range temporal correlations (LRTCs), while only BDNF polymorphism affected the strength of large-scale synchronization. Our findings demonstrate that COMT and BDNF genetic polymorphisms contribute to inter-individual variability in local and large-scale synchronization dynamics of neuronal oscillations. Comparison of these results to computational modelling of near-critical synchronization dynamics further suggested that COMT and BDNF polymorphisms influenced local oscillations by modulating the excitation-inhibition balance according to the brain criticality framework. |
| Databáze: | OpenAIRE |
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