The Role of Galectin-1 in Cancer Progression, and Synthetic Multivalent Systems for the Study of Galectin-1

Autor: Mary J. Cloninger, Jonathan M. Cousin
Rok vydání: 2016
Předmět:
0301 basic medicine
Galectin 1
Rotaxanes
Angiogenesis
Review
dendrimer
lcsh:Chemistry
Extracellular matrix
0302 clinical medicine
Neoplasms
Tumor Microenvironment
multivalent
lcsh:QH301-705.5
Spectroscopy
Neovascularization
Pathologic
General Medicine
Small molecule
Extracellular Matrix
Computer Science Applications
Cell biology
Biochemistry
030220 oncology & carcinogenesis
Galectin-1
Dendrimers
animal structures
Poloxamer
Biology
Catalysis
Inorganic Chemistry
03 medical and health sciences
Cell Adhesion
otorhinolaryngologic diseases
medicine
Animals
Humans
galectin-1
Neoplasm Invasiveness
Physical and Theoretical Chemistry
Cell adhesion
Molecular Biology
Galectin
Cyclodextrins
Tumor microenvironment
glycodendrimer
Organic Chemistry
Cancer
medicine.disease
stomatognathic diseases
030104 developmental biology
galectins
lcsh:Biology (General)
lcsh:QD1-999
Zdroj: International Journal of Molecular Sciences, Vol 17, Iss 9, p 1566 (2016)
International Journal of Molecular Sciences
ISSN: 1422-0067
DOI: 10.3390/ijms17091566
Popis: This review discusses the role of galectin-1 in the tumor microenvironment. First, the structure and function of galectin-1 are discussed. Galectin-1, a member of the galectin family of lectins, is a functionally dimeric galactoside-binding protein. Although galectin-1 has both intracellular and extracellular functions, the defining carbohydrate-binding role occurs extracellularly. In this review, the extracellular roles of galectin-1 in cancer processes are discussed. In particular, the importance of multivalent interactions in galectin-1 mediated cellular processes is reviewed. Multivalent interactions involving galectin-1 in cellular adhesion, mobility and invasion, tumor-induced angiogenesis, and apoptosis are presented. Although the mechanisms of action of galectin-1 in these processes are still not well understood, the overexpression of galectin-1 in cancer progression indicates that the role of galectin-1 is significant. To conclude this review, synthetic frameworks that have been used to modulate galectin-1 processes are reviewed. Small molecule oligomers of carbohydrates, carbohydrate-functionalized pseudopolyrotaxanes, cyclodextrins, calixarenes, and glycodendrimers are presented. These synthetic multivalent systems serve as important tools for studying galectin-1 mediated cancer cellular functions.
Databáze: OpenAIRE
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