Risk of cardiovascular disease with lipoprotein(a) in familial hypercholesterolemia: a review
| Autor: | Kazuhiko Kotani, Masato Hamasaki, Jun Watanabe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
biology business.industry Hazard ratio General Medicine Lipoprotein(a) Odds ratio Familial hypercholesterolemia medicine.disease apoprotein(a) Confidence interval Internal medicine Relative risk medicine biology.protein Risk factor coronary heart disease business State of the Art Paper coronary artery disease Cohort study |
| Zdroj: | Archives of Medical Sciences. Atherosclerotic Diseases |
| ISSN: | 2451-0629 |
| Popis: | IntroductionLipoprotein(a) (Lp[a]) is a risk factor of cardiovascular disease (CVD). Familial hypercholesterolemia (FH), which exhibits high low-density lipoprotein cholesterol (LDL-C) levels, is a risk factor of CVD. The relationship of Lp(a) with CVD has been characterized in populations specific to FH.Material and methodsStudies reporting on the relationship of Lp(a) with CVD among FH subjects via PubMed up to 2020 were reviewed.ResultsEight studies were identified as eligible. In the meta-analyses, a high Lp(a) level was significantly and predictively associated with CVD compared to a low Lp(a) level in 2 cross-sectional studies (odds ratio = 2.57; 95% confidence interval (CI): 1.16–5.73) and 6 cohort studies (risk/hazard ratio = 1.91; 95% CI: 1.50–2.43). The totally integrated relative risk of these studies was 1.97 (95% CI: 1.57–2.46).ConclusionsFH subjects with high Lp(a) levels can have a high CVD risk, and besides LDL-C, attention should be paid to Lp(a) levels in FH subjects. |
| Databáze: | OpenAIRE |
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