Conventional versus Ultrapure Dialysate for Lowering Serum Lipoprotein(a) Levels in Patients on Long-Term Hemodialysis: A Randomized Trial
| Autor: | Jian-ling Tao, Lin Duan, Xuemei Li, Yang Sun, Shi-Qin Liu, Xuewang Li, Yan Li, Yubing Wen, Hang Li |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Time Factors Polymers medicine.medical_treatment 030232 urology & nephrology Medicine (miscellaneous) 030204 cardiovascular system & hematology Gastroenterology Hemoglobins 0302 clinical medicine Sulfones biology General Medicine Lipoprotein(a) Middle Aged Recombinant Proteins C-Reactive Protein Treatment Outcome Cardiovascular Diseases Female Hemodialysis Inflammation Mediators medicine.drug medicine.medical_specialty Biomedical Engineering Down-Regulation Bioengineering Biomaterials 03 medical and health sciences Nephelometry and Turbidimetry Renal Dialysis Internal medicine medicine Humans Erythropoietin Serum Albumin Dialysis Aged Interleukin-6 business.industry Beta-2 microglobulin Albumin Membranes Artificial Hemodialysis Solutions Endotoxins Endocrinology Hematinics biology.protein Kidney Failure Chronic Hemoglobin beta 2-Microglobulin business Biomarkers Lipoprotein |
| Zdroj: | The International Journal of Artificial Organs. 33:290-296 |
| ISSN: | 1724-6040 0391-3988 |
| DOI: | 10.1177/039139881003300504 |
| Popis: | Purpose In patients on long-term hemodialysis, high lipoprotein(a) [Lp(a)] levels are difficult to lower with medications, although they remain a risk factor for cardiovascular disease. We investigated whether ultrapure dialysate (UPD) could lower Lp(a). Methods: We randomly assigned patients stabilized on long-term dialysis to either a low-flux synthetic polysulphone membrane (the UPD group; n=14) or to a conventional dialysate (the CD group; n=13). Blood samples were collected 1 week before dialysis and 1 week, 1 month, 6 months and 12 months after dialysis; Lp(a) was measured by the immunotur-bidimetry method. Hemoglobin, interleukin-6, hypersensitive C-reactive protein, β2 microglobulin and albumin were also measured. The erythropoietin dosage, Kt/V, and normalized protein catabolic rate were recorded monthly. Results At 12 months, mean (SD) serum levels of Lp(a) in the CD patients increased from 143.46 (125.11) to 283.89 (145.81) mg/L (pConclusions Ultrapure dialysate can prevent the rise of Lp(a), potentially decreasing the risk of cardiovascular disease in hemodialysis patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|